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ITSN1 gene

Known as: ITSN, SH3 DOMAIN PROTEIN 1A, Src homology 3 domain-containing protein 
This gene plays a role in both signal transduction and endocytosis.
National Institutes of Health

Related topics

Related topics

5 relations
EndocytosisITSN1 protein, humanSignal Transductionintersectin 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Intersectin 1 forms a complex with adaptor protein Ruk/CIN85 in vivo independently of epidermal growth factor stimulation.
Highly Cited
2007
Highly Cited
2007
Intersectin links WNK kinases to endocytosis of ROMK1.
With-no-lysine (WNK) kinases are a novel family of protein kinases characterized by an atypical placement of the catalytic lysine… 
Highly Cited
2007
Highly Cited
2007
RAB-10 regulates glutamate receptor recycling in a cholesterol-dependent endocytosis pathway.
Regulated endocytosis of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptors (AMPARs) is critical… 
Highly Cited
2007
Highly Cited
2007
Regulation of Neuron Survival through an Intersectin-Phosphoinositide 3′-Kinase C2β-AKT Pathway
ABSTRACT While endocytosis attenuates signals from plasma membrane receptors, recent studies suggest that endocytosis also serves… 
Review
2007
Review
2007
Intersectin enhances huntingtin aggregation and neurodegeneration through activation of c-Jun-NH2-terminal kinase.
Huntingon's disease is a progressive neurodegenerative disease arising from expansion of a polyglutamine (polyQ) tract in the… 
Highly Cited
2006
Highly Cited
2006
Intersectin Regulates Epidermal Growth Factor Receptor Endocytosis, Ubiquitylation, and Signaling
Receptor tyrosine kinases (RTKs) are critical for normal cell growth, differentiation, and development, but they contribute to… 
Highly Cited
2003
Highly Cited
2003
Intersectin Activates Ras but Stimulates Transcription through an Independent Pathway Involving JNK*
Intersectin (ITSN) is a molecular scaffold involved in regulating endocytosis and mitogenic signaling. We previously demonstrated… 
Highly Cited
2000
Highly Cited
2000
Intersectin 2, a new multimodular protein involved in clathrin‐mediated endocytosis
Highly Cited
1999
Highly Cited
1999
Alu-splice cloning of human Intersectin (ITSN), a putative multivalent binding protein expressed in proliferating and differentiating neurons and overexpressed in Down syndrome
By Alu-splice PCR we have trapped two exons and subsequently identified the full length cDNA of a human gene, Intersectin (ITSN… 
Highly Cited
1998
Highly Cited
1998
Two isoforms of a human intersectin (ITSN) protein are produced by brain-specific alternative splicing in a stop codon.
Using selected trapped exons with homology to specific protein domains, we identified a new full-length cDNA encoding a protein… 
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