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ITPR1 wt Allele

Known as: ITPR1, IP3R, Inositol 1,4,5-Triphosphate Receptor, Type 1 Gene 
Human ITPR1 wild-type allele is located within 3p26-p25 and is approximately 354 kb in length. This allele, which encodes inositol 1,4,5… 
National Institutes of Health

Related topics

Related topics

11 relations
3p26-p25Alzheimer's Disease Pathway KEGGCalcium BindingCalcium Signaling

Papers overview

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Highly Cited
2014
Highly Cited
2014
Yeast Osmosensors Hkr1 and Msb2 Activate the Hog1 MAPK Cascade by Different Mechanisms
Apparent redundancy in two yeast osmosensors instead confers specificity in coupling internal and external signals. Not So… 
Highly Cited
2007
Highly Cited
2007
Heterozygous deletion of ITPR1, but not SUMF1, in spinocerebellar ataxia type 16
We have previously mapped autosomal dominant spinocerebellar ataxia (SCA) 16 to 3p26, overlapping with the locus of SCA15… 
Highly Cited
2004
Highly Cited
2004
Caspase-3-induced Truncation of Type 1 Inositol Trisphosphate Receptor Accelerates Apoptotic Cell Death and Induces Inositol Trisphosphate-independent Calcium Release during Apoptosis*
Inositol 1,4,5-trisphosphate receptor-deficient (IP3RKO) B-lymphocytes were used to investigate the functional relevance of type… 
Highly Cited
2002
Highly Cited
2002
Cell cycle-dependent assembly of a Gin4-septin complex.
Gin4, a Nim1-related kinase, is required in budding yeast for localization of the septins and for proper control of daughter cell… 
Highly Cited
2000
Highly Cited
2000
Phosphorylation of the Cdc42 exchange factor Cdc24 by the PAK-like kinase Cla4 may regulate polarized growth in yeast.
Highly Cited
1999
Highly Cited
1999
Differential cellular expression of isoforms of inositol 1,4,5‐triphosphate receptors in neurons and glia in brain
Inositol 1,4,5‐trisphosphate receptors (IP3R) are mediators of second messenger‐induced intracellular calcium release. Three… 
Highly Cited
1997
Highly Cited
1997
Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5‐trisphosphate receptors in signal transduction through the B‐cell antigen receptor
Stimulation of B‐cell antigen receptor (BCR) induces a rapid increase in cytoplasmic free calcium due to its release from… 
Highly Cited
1997
Highly Cited
1997
T cells deficient in inositol 1,4,5-trisphosphate receptor are resistant to apoptosis
The type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) calcium release channel is present on the endoplasmic reticulum of most… 
Highly Cited
1996
Highly Cited
1996
Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor
THE inositol 1,4,5-trisphosphate (InsP3) receptor acts as an InsP3-gated Ca2+ release channel in a variety of cell types1,2. Type… 
Highly Cited
1996
Highly Cited
1996
Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast.
STE20 encodes a protein kinase related to mammalian p65Pak which functions in several signal transduction pathways in yeast… 
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