Skip to search formSkip to main contentSkip to account menu

ISIS 3521

Known as: ISIS3521, isis-3521 
A synthetic phosphorothioate oligodeoxynucleotide. As an antisense molecule, ISIS 3521 hybridizes to the 3-untranslated region of the human protein… 
National Institutes of Health

Related topics

Related topics

7 relations

Narrower (3)

AffinitacAffinitakLY900003
ISI 641Acisplatin/gemcitabine/ISIS 3521

Broader (2)

Protein Kinase C-Alpha AntisenseThionucleotides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2007
Review
2007
Enzastaurin , a Protein Kinase C B ^ Selective Inhibitor , and Its PotentialApplicationasanAnticancer AgentinLungCancer
Enzastaurin, an oral serine/threonine kinase inhibitor, suppresses signaling throughprotein kinase C (PKC)-h and the… 
2003
2003
Antisense candidates against protein kinase C-alpha designed based on phylogenesis and simulant structure of mRNA.
AIM To optimize the antisense drug design by the combined method of phylogenetic analysis and secondary structure prediction and… 
2003
2003
Protein Kinase C Is a Prosurvival Factor in Human Breast Tumor Cell Lines 1
Protein kinase C (PKC) promotes cell survival in response to ionizing radiation in a variety of experimental models including… 
Highly Cited
2002
Highly Cited
2002
A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer.
PURPOSE Protein kinase C (PKC)-alpha and Raf-1 are important elements of proliferative signal transduction pathways in both… 
2002
2002
Protamine-fragment peptides fused to an SV40 nuclear localization signal deliver oligonucleotides that produce antisense effects in prostate and bladder carcinoma cells.
The development of antisense technology has focused on improving methods for oligonucleotide delivery into cells. In the present… 
2002
2002
A Randomized Phase II and Pharmacokinetic Study of the Antisense Oligonucleotides ISIS 3521 and ISIS 5132 in Patients with Hormone-refractory Prostate Cancer 1
Purpose: Protein kinase C (PKC)and Raf-1 are important elements of proliferative signal transduction pathways in both normal and… 
2002
2002
Phase II Randomized Study of ISIS 3521 and ISIS 5132 in Patients with Locally Advanced or Metastatic Colorectal Cancer : A National Cancer Institute of Canada Clinical Trials Group Study 1
Background: Because treatment of metastatic colon cancer is noncurative, new treatments are needed. This trial evaluated the… 
Review
2001
Review
2001
ISIS-3521. Isis Pharmaceuticals.
ISIS-3521 is a 20-mer antisense phosphorothioate oligonucleotide PKCa expression inhibitor, under development by Isis (formerly… 
2000
2000
Application of secondary structure prediction in antisense drug design targeting protein kinase C-alpha mRNA and QSAR analysis.
AIM To optimize the design of antisense drug targeting protein kinase C-alpha (PKC-alpha) mRNA and obtain better antisense drugs… 
Highly Cited
1998
Highly Cited
1998
Antitumor activity of a PKC-alpha antisense oligonucleotide in combination with standard chemotherapeutic agents against various human tumors transplanted into nude mice.
A 20-mer phosphorothioate oligodeoxynucleotide (ODN) directed against human protein kinase C-alpha (CGP 64128A = ISIS 3521) was… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)