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IQGAP2 gene

Known as: IQGAP2, IQ Motif Containing GTPase Activating Protein 2 Gene, IQ MOTIF-CONTAINING GTPase-ACTIVATING PROTEIN 2 
This gene plays a role in the regulation of Ras superfamily GTPase activity.
National Institutes of Health

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Related topics

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Signal Transduction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
IQGAP2 acts as a tumor suppressor in breast cancer and its reduced expression promotes cancer growth and metastasis by MEK/ERK signalling pathways
IQGAP2 is a member of IQGAPs scaffolding protein family. It has been reported as a tumor suppressor in various cancers, as well… 
2016
2016
Targeted Sequencing and Meta-Analysis of Preterm Birth
Understanding the genetic contribution(s) to the risk of preterm birth may lead to the development of interventions for treatment… 
2016
2016
Integrated genomic profiling identifies microRNA‐92a regulation of IQGAP2 in locally advanced rectal cancer
Locally advanced rectal cancer (LARC) is treated with chemoradiation prior to surgical excision, leaving residual tumors altered… 
2015
2015
Epigenetic regulation of IQGAP 2 promotes ovarian cancer progression via activating Wnt / β-catenin signaling
Ovarian cancer is the most lethal gynecologic malignancy and most cases are diagnosed at an advanced stage with metastases… 
2014
2014
Conserved sequence repeats of IQGAP1 mediate binding to Ezrin.
Mammalian IQGAP proteins all feature multiple ∼50 amino acid sequence repeats near their N-termini, and little is known about the… 
2013
2013
Transcript Profiling Identifies Iqgap2−/− Mouse as a Model for Advanced Human Hepatocellular Carcinoma
It is broadly accepted that genetically engineered animal models do not always recapitulate human pathobiology. Therefore… 
2012
2012
Watch the GAP: Emerging Roles for IQ Motif-Containing GTPase-Activating Proteins IQGAPs in Hepatocellular Carcinoma
IQ motif-containing GTPase-activating proteins IQGAP1 and IQGAP2 are highly homologous multidomain scaffolding proteins. Their… 
2012
2012
Four new loci associations discovered by pathway-based and network analyses of the genome-wide variability profile of Hirschsprung’s disease
Finding gene associations in rare diseases is frequently hampered by the reduced numbers of patients accessible. Conventional… 
Highly Cited
2009
Highly Cited
2009
Gemcitabine and Arabinosylcytosin Pharmacogenomics: Genome-Wide Association and Drug Response Biomarkers
Cancer patients show large individual variation in their response to chemotherapeutic agents. Gemcitabine (dFdC) and AraC, two… 
2005
2005
IQGAPs are differentially expressed and regulated in polarized gastric epithelial cells.
IQGAPs, GTPase-activating proteins with an IQ motif, are thought to regulate many actin cytoskeleton-based activities through… 
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