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FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt.
Akt is a central regulator of cell growth. Its activity can be negatively regulated by the phosphatase PHLPP that specifically dephosphorylates the hydrophobic motif of Akt (Ser473 in Akt1). However,… Expand
Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case–control studies
Summary Background Endometriosis is a risk factor for epithelial ovarian cancer; however, whether this risk extends to all invasive histological subtypes or borderline tumours is not clear. We… Expand
Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer.
CONTEXT Approximately 10% of women with invasive epithelial ovarian cancer (EOC) carry deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2-related EOC was… Expand
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ∼480 SNPs at the TERT locus in… Expand
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24
Ovarian cancer accounts for more deaths than all other gynecological cancers combined. To identify common low-penetrance ovarian cancer susceptibility genes, we conducted a genome-wide association… Expand
Practical Guidelines for Assessing the Clinical Significance of Health-Related Quality of Life Changes within Clinical Trials
Health-related quality of life (HRQOL) assessment is becoming common practice in many clinical trials. There is much debate over how to determine the clinical significance of changes in HRQOL scores.… Expand
Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis consortium study.
BACKGROUND Few biomarkers of ovarian cancer prognosis have been established, partly because subtype-specific associations might be obscured in studies combining all histopathological subtypes. We… Expand
Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer.
- S. Ramus, H. Song, +40 authors S. Gayther
- Biology, Medicine
- Journal of the National Cancer Institute
- 1 November 2015
BACKGROUND Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, responsible for 13 000 deaths per year in the United States. Risk prediction based on identifying germline… Expand
Gene set analysis of SNP data: benefits, challenges, and future directions
The last decade of human genetic research witnessed the completion of hundreds of genome-wide association studies (GWASs). However, the genetic variants discovered through these efforts account for… Expand
Toll-like receptor polymorphisms and age-related macular degeneration.
- A. Edwards, D. Chen, +11 authors N. Tosakulwong
- Biology, Medicine
- Investigative ophthalmology & visual science
- 1 April 2008
PURPOSE Evidence from genetic-association studies in conjunction with the demonstration of complement deposition in the retina and choroid implicates noncellular pathways of innate immunity in the… Expand