INCB3344
National Institutes of Health
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Macrophages accumulate in blood vessels during hypertension. However, their contribution to vessel remodeling is unknown. In the…
Background and Purpose— Ly6Chi monocytes are generally thought to exert a proinflammatory role in acute tissue injury, although…
Chemokine (C‐C motif) ligand 2 (CCL2) participates in different mechanisms contributing to the spinal cord inflammation and pain…
The chemokine receptor CCR2 is a G protein–coupled receptor that is activated primarily by the endogenous CC chemokine ligand 2…
Infiltration of macrophages into the artery wall plays detrimental roles during hypertension by promoting vascular inflammation…
Changes in function of voltage-gated sodium channels in nociceptive primary sensory neurons participate in the development of…
Purpose To investigate the effect of an intravitreally administered CCR2 antagonist, INCB3344, on a mouse model of choroidal…
This report describes the characterization of INCB3344, a novel, potent and selective small molecule antagonist of the mouse CCR2…