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INCB3344

 
National Institutes of Health

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1 relation

Broader (1)

Pyrrolidines

Papers overview

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Highly Cited
2015
Highly Cited
2015
M2 macrophage accumulation in the aortic wall during angiotensin II infusion in mice is associated with fibrosis, elastin loss, and elevated blood pressure.
Macrophages accumulate in blood vessels during hypertension. However, their contribution to vessel remodeling is unknown. In the… Expand
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Highly Cited
2015
Highly Cited
2015
Evidence That Ly6Chi Monocytes Are Protective in Acute Ischemic Stroke by Promoting M2 Macrophage Polarization
Background and Purpose— Ly6Chi monocytes are generally thought to exert a proinflammatory role in acute tissue injury, although… Expand
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2014
2014
Implication of the chemokine CCL2 in trigeminal nociception and traumatic neuropathic orofacial pain
Chemokine (C‐C motif) ligand 2 (CCL2) participates in different mechanisms contributing to the spinal cord inflammation and pain… Expand
2013
2013
Multiple Binding Sites for Small-Molecule Antagonists at the CC Chemokine Receptor 2
The chemokine receptor CCR2 is a G protein–coupled receptor that is activated primarily by the endogenous CC chemokine ligand 2… Expand
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Highly Cited
2012
Highly Cited
2012
Reversal of Vascular Macrophage Accumulation and Hypertension by a CCR2 Antagonist in Deoxycorticosterone/Salt-Treated Mice
Infiltration of macrophages into the artery wall plays detrimental roles during hypertension by promoting vascular inflammation… Expand
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2011
2011
Suppression and Regression of Choroidal Neovascularization in Mice by a Novel CCR2 Antagonist, INCB3344
Purpose To investigate the effect of an intravitreally administered CCR2 antagonist, INCB3344, on a mouse model of choroidal… Expand
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Highly Cited
2011
Highly Cited
2011
The Chemokine CCL2 Increases Nav1.8 Sodium Channel Activity in Primary Sensory Neurons through a Gβγ-Dependent Mechanism
Changes in function of voltage-gated sodium channels in nociceptive primary sensory neurons participate in the development of… Expand
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2010
2010
Discovery of INCB3344, a potent, selective and orally bioavailable antagonist of human and murine CCR2.
Rational design based on a pharmacophore of CCR2 antagonists reported in the literature identified lead compound 9a with potent… Expand
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2009
2009
Pharmacological characterization of INCB3344, a small molecule antagonist of human CCR2.
The chemokine receptor 2 (CCR2) directs migration of monocytes and has been proposed to be a drug target for chronic inflammatory… Expand
Highly Cited
2005
Highly Cited
2005
Discovery and Pharmacological Characterization of a Novel Rodent-Active CCR2 Antagonist, INCB3344
This report describes the characterization of INCB3344, a novel, potent and selective small molecule antagonist of the mouse CCR2… Expand
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