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IMGN529
Known as:
Anti-CD37 Antibody-Drug Conjugate IMGN529
, IMGN529 conjugate
An immunoconjugate that consists of a humanized IgG1 antibody K7153A against the cell-surface antigen CD37 and covalently linked via the uncleavable…
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National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
Antibodies, Monoclonal, Humanized
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
The Antitumor Activity of IMGN529, a CD37-Targeting Antibody-Drug Conjugate, Is Potentiated by Rituximab in Non-Hodgkin Lymphoma Models
S. Hicks
,
Katharine C. Lai
,
+9 authors
A. Romanelli
Neoplasia
2017
Corpus ID: 7301838
2016
2016
Identification of Anti-Lymphoma Biomarkers of Response to the Anti-CD37 Antibody Drug Conjugate (ADC) IMGN529
E. Gaudio
,
C. Tarantelli
,
+11 authors
F. Bertoni
2016
Corpus ID: 91128027
Background IMGN529 is an antibody drug conjugate (ADC) consisting of an anti-CD37 antibody with direct anti-tumor activity…
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2015
2015
IMGN529, a Novel Antibody-Drug Conjugate (ADC) Targeting CD37 Shows Synergistic Activity with Rituximab in Non-Hodgkin Lymphoma (NHL) Models
Jutta Deckert
,
C. Sloss
,
+7 authors
A. Romanelli
2015
Corpus ID: 78630115
Introduction: Relapsed/refractory B-cell NHL remains an area of significant medical need. CD37 is highly expressed in many B-cell…
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2014
2014
A Phase I Study of IMGN529, an Antibody-Drug Conjugate (ADC) Targeting CD37, in Adult Patients with Relapsed or Refractory B-Cell Non-Hodgkin’s Lymphoma (NHL)
A. Stathis
,
A. Freedman
,
+10 authors
L. Palomba
2014
Corpus ID: 78398539
Background: While CD37 is widely expressed on malignant B cells in NHL and chronic lymphocytic leukemia (CLL), few therapies are…
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Review
2014
Review
2014
Anti-CD37 antibodies for chronic lymphocytic leukemia
T. Robak
,
P. Robak
Expert Opinion on Biological Therapy
2014
Corpus ID: 19987961
Introduction: Immunotherapy using mAbs is a safe and effective method for the treatment of chronic lymphocytic leukemia (CLL) and…
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2014
2014
Preliminary findings from a phase I, multicenter, open-label study of the anti-CD37 antibody-drug conjugate (ADC), IMGN529, in adult patients with relapsed or refractory non-Hodgkin lymphoma (NHL).
A. Stathis
,
K. Maddocks
,
+7 authors
A. Freedman
2014
Corpus ID: 79089588
8526 Background: IMGN529 is a CD37-targeting ADC comprising a CD37-binding antibody conjugated to the maytansinoid anti-mitotic…
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2012
2012
Fourth World Antibody-Drug Conjugate Summit
A. Beck
,
J. Lambert
,
Michael M C Sun
,
Kedan Lin
mAbs
2012
Corpus ID: 13104188
The 4th World Antibody Drug Conjugate (WADC) Summit, organized by Hanson Wade was held on February 29‑March 1, 2012 in Frankfurt…
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2011
2011
Potent B-Cell Depletion by IMGN529, a CD37-Targeting Antibody-Maytansinoid Conjugate for the Treatment of B-Cell Malignancies,
Jutta Deckert
,
Sharon Chicklas
,
+5 authors
Peter U Park
2011
Corpus ID: 90310324
Abstract 3726 CD37 is a B-cell surface antigen which is widely expressed on malignant B cells in non-Hodgkin9s lymphoma (NHL) and…
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2011
2011
Abstract 2830: Antibody and linker selection for the anti-CD37 antibody-maytansinoid conjugate IMGN529 for the treatment of B-cell malignancies
Peter U Park
,
Y. Yi
,
+7 authors
T. Chittenden
2011
Corpus ID: 70783705
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL CD37 represents an attractive target for an antibody…
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2011
2011
Abstract 4565: IMGN529: A therapeutic maytansinoid conjugate of an anti-CD37 antibody with multiple mechanisms of action for B-cell lymphoma and leukemia
Jutta Deckert
,
M. Mayo
,
+8 authors
Peter U Park
2011
Corpus ID: 72084636
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL CD37 is a B-cell surface antigen that is an attractive…
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