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IMC-3G3

National Institutes of Health

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Broader (2)

Monoclonal Antibodiesolaratumab

Papers overview

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2014
2014
Phase I study of olaratumab in Japanese patients with advanced solid tumors
Olaratumab (IMC‐3G3) is a fully human IgG1 monoclonal antibody that selectively binds the external domain of human platelet… 
2010
2010
Randomized phase II study of human anti-platelet-derived growth factor receptor alpha (PDGFRα) monoclonal antibody (IMC-3G3) with paclitaxel/carboplatin (P/C) or P/C alone in first-line treatment of…
TPS296 Background: This study, scheduled to begin enrollment in January 2010, will evaluate P/C alone or with IMC-3G3 in first… 
2010
2010
Abstract 1468: Antagonism of platelet-derived growth factor receptor-α as a potential therapeutic for prostate cancer bone metastases
Prostate adenocarcinoma is the second leading cause of cancer death among men, due primarily to the fact that the majority of… 
2010
2010
Abstract 1793: Platelet-derived growth factor receptor alpha blockade significantly enhances sensitization to docetaxel in ovarian carcinoma
Objective: Platelet-derived growth factor receptor alpha (PDGFRα) is a member of class III receptor tyrosine kinase and is… 
2008
2008
Phase 1 study of IMC-3G3, an IgG1 monoclonal antibody targeting PDGFR{alpha} in patients with advanced solid malignancies
14617 Background: Platelet derived growth factor receptor alpha (PDGFRα) plays a critical role in tumorigenesis and tumor… 
2008
2008
511 POSTER Phase I study of IMC-3G3, an IgG1 monoclonal antibody targeting platelet-derived growth factor alpha (PDGFRa) in patients with advanced solid malignancies
2008
2008
Human bone marrow activates the Akt pathway in metastatic prostate cells through transactivation of the α-platelet-derived growth factor receptor. Dolloff NG, Russell MR, Loizos N, Fatatis A…
2007
2007
Human Bone Marrow Activates the Akt Pathway in Metastatic Prostate Cells through Transactivation of the α-Platelet–Derived Growth Factor Receptor
The factors regulating the bone tropism of disseminated prostate cancer cells are still vaguely defined. We report that prostate… 
2007
2007
Human bone marrow activates the Akt pathway in metastatic prostate cells through transactivation of the alpha-platelet-derived growth factor receptor.
The factors regulating the bone tropism of disseminated prostate cancer cells are still vaguely defined. We report that prostate… 
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