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IL34 gene

Known as: Interleukin 34 Gene, MGC34647, INTERLEUKIN 34 
This gene plays a role in receptor binding and cytokine-dependent signaling.
National Institutes of Health

Related topics

Related topics

8 relations
Cell Proliferation Regulatory ProcessCytokine Receptor BindingCytokine SignalingImmune Cell Activation Process
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Reverse genetic screen reveals that Il34 facilitates yolk sac macrophage distribution and seeding of the brain
ABSTRACT Microglia are brain-resident macrophages, which have specialized functions important in brain development and in disease… Expand
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2019
2019
Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer
Colony-stimulating factor 1 (CSF1) and interleukin 34 (IL34) signal via the CSF1 receptor to regulate macrophage differentiation… Expand
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Review
2017
Review
2017
CSF-1R Inhibitor Development: Current Clinical Status
Purpose of ReviewColony-stimulating factor 1 receptor (CSF-1R) and its ligands, CSF-1 and interleukin 34 (IL-34), regulate the… Expand
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Highly Cited
2016
Highly Cited
2016
Chemotherapy-Induced IL34 Enhances Immunosuppression by Tumor-Associated Macrophages and Mediates Survival of Chemoresistant Lung Cancer Cells.
The ability of tumor cells to escape immune destruction and their acquired resistance to chemotherapy are major obstacles to… Expand
2016
2016
CSF1 Overexpression Promotes High-Grade Glioma Formation without Impacting the Polarization Status of Glioma-Associated Microglia and Macrophages.
Current therapies for high-grade gliomas extend survival only modestly. The glioma microenvironment, including glioma-associated… Expand
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2014
2014
Production and characterisation of a monoclonal antibody that recognises the chicken CSF1 receptor and confirms that expression is restricted to macrophage-lineage cells.
Macrophages contribute to innate and acquired immunity as well as many aspects of homeostasis and development. Studies of… Expand
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Highly Cited
2013
Highly Cited
2013
Increased Levels of Interleukin 34 in Serum and Synovial Fluid Are Associated with Rheumatoid Factor and Anticyclic Citrullinated Peptide Antibody Titers in Patients with Rheumatoid Arthritis
Objective. Interleukin 34 (IL-34) is a recently discovered cytokine that binds macrophage colony-stimulating factor (M-CSF… Expand
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Highly Cited
2012
Highly Cited
2012
IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia
The differentiation of bone marrow–derived progenitor cells into monocytes, tissue macrophages and some dendritic cell (DC… Expand
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2012
2012
Increased Serum Interleukin-34 in Patients with Coronary Artery Disease
Objective: This study investigated levels of interleukin (IL)-34, a proinflammatory cytokine, in patients with coronary artery… Expand
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2012
2012
The yin-yang nature of CSF1R-binding cytokines
Most myeloid cells express the growth-factor receptor CSF1R. Recognition of interleukin 34 by CSF1R is required for the… Expand
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