IL-10 Immunomodulator MK-1966

Known as: MK 1966, MK-1966 
An agent that downregulates the activity of the anti-inflammatory cytokine human interleukin-10 (IL-10), with potential immunomodulating and… (More)
National Institutes of Health

Papers overview

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2006
2006
Mesangial cells initiate compensatory renal tubular hypertrophy via IL-10-induced TGF-beta secretion: effect of the immunomodulator AS101 on this process.
The present study investigated the role of IL-10 produced by the mesangial cells in postnephrectomy compensatory renal growth and… (More)
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2006
2006
Fat-derived hormone adiponectin combined with FTY720 significantly improves small-for-size fatty liver graft survival.
Owing to the discrepancy between organ donation and the demand for liver transplantation, expanding the liver donor pool is of… (More)
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2000
2000
Linomide abolishes leukocyte adhesion and extravascular recruitment induced by tumor necrosis factor alpha in vivo.
The immunomodulator Linomide (roquinimex) ameliorates the development of numerous inflammatory and immunological diseases… (More)
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1998
1998
IgA B and T cells in the intestinal Villi of immunodeficient rats orally treated with thymomodulin.
Previous studies on the effect of the oral administration of bacterial immunomodulators (1M-104 and RN-301) during the protein… (More)
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1997
1997
Delay in the onset of systemic lupus erythematosus following treatment with the immunomodulator AS101: association with IL-10 inhibition and increase in TNF-alpha levels.
It has recently been found that in systemic lupus erythematosus (SLE), a multisystem inflammatory disorder characterized by… (More)
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1996
1996
The protective role of the immunomodulator AS101 against chemotherapy-induced alopecia studies on human and animal models.
The immunomodulator AS101 has been demonstrated to exhibit radioprotective and chemoprotective effects in mice. Following phase-I… (More)
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1996
1996
Antibabesial effect of the immunomodulator AS101 in mice: role of increased production of nitric oxide.
The immunomodulator AS101 has been shown to induce cell proliferation and to increase the secretion of a variety of cytokines. In… (More)
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1995
1995
Induction of acute phase proteins in mice and humans by treatment with AS101, an immunomodulator with radioprotective properties.
AS101 (ammonium trichloro(dioxyethylene-0,0')tellurate) is a new synthetic compound previously described by us as having… (More)
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1994
1994
Restoration of murine cytomegalovirus (MCMV) induced myelosuppression by AS101.
Infection with cytomegalovirus (CMV) continues to be one of the most common complications following allogeneic bone marrow… (More)
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1992
1992
The immunomodulator AS101 administered orally as a chemoprotective and radioprotective agent.
AS101 [ammonium-trichloro (0,0' dioxyethylene)tellurate] is a new immunomodulator shown previously to stimulate the production of… (More)
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