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IL-10 Immunomodulator MK-1966

Known as: MK 1966, MK-1966 
An agent that downregulates the activity of the anti-inflammatory cytokine human interleukin-10 (IL-10), with potential immunomodulating and… 
National Institutes of Health

Papers overview

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2006
2006
Mesangial cells initiate compensatory renal tubular hypertrophy via IL-10-induced TGF-beta secretion: effect of the immunomodulator AS101 on this process.
The present study investigated the role of IL-10 produced by the mesangial cells in postnephrectomy compensatory renal growth and… 
2006
2006
Retracted: Fat‐Derived Hormone Adiponectin Combined with FTY720 Significantly Improves Small‐for‐Size Fatty Liver Graft Survival
Owing to the discrepancy between organ donation and the demand for liver transplantation, expanding the liver donor pool is of… 
2000
2000
Linomide abolishes leukocyte adhesion and extravascular recruitment induced by tumor necrosis factor α in vivo
The immunomodulator Linomide (roquinimex) ameliorates the development of numerous inflammatory and immunological diseases… 
Highly Cited
1997
Highly Cited
1997
Delay in the onset of systemic lupus erythematosus following treatment with the immunomodulator AS101: association with IL-10 inhibition and increase in TNF-alpha levels.
It has recently been found that in systemic lupus erythematosus (SLE), a multisystem inflammatory disorder characterized by… 
Highly Cited
1996
Highly Cited
1996
The protective role of the immunomodulator AS101 against chemotherapy‐induced alopecia studies on human and animal models
The immunomodulator AS101 has been demonstrated to exhibit radioprotective and chemoprotective effects in mice. Following phase‐I… 
1996
1996
Antibabesial effect of the immunomodulator AS101 in mice: role of increased production of nitric oxide
The immunomodulator AS101 has been shown to induce cell proliferation and to increase the secretion of a variety of cytokines. In… 
1994
1994
Restoration of murine cytomegalovirus (MCMV) induced myelosuppression by AS101.
Highly Cited
1992
Highly Cited
1992
The immunomodulator AS101 administered orally as a chemoprotective and radioprotective agent.
1991
1991
Transplantation of Purified Islet Cells in Diabetic Rats: III. Immunosuppressive Effect of Cyclosporin
This study examined the effect of cyclosporin on the survival of islet β-cell allografts in streptozocin (STZ)-induced diabetic… 
1990
1990
The effect of the immunomodulator agent AS101 on interleukin‐2 production in systemic lupus erythematosus (SLE) induced in mice by a pathogenic anti‐DNA antibody
The role of the synthetic immunomodulator AS101 on the production of interleukin‐2 (IL‐2) by spleen cells of mice with SLE was… 
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