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Patient-specific induced pluripotent stem cells (iPSCs) represent a novel system for modeling human genetic disease and could… Expand ABSTRACT Familial dysautonomia (FD), a devastating hereditary sensory and autonomic neuropathy, results from an intronic mutation… Expand The activation of Rab GTPases is a critical focal point of membrane trafficking events in eukaryotic cells; however, the cellular… Expand ABSTRACT To physically characterize the web of interactions connecting the Saccharomyces cerevisiae proteins suspected to be RNA… Expand Human Elongator complex was purified to virtual homogeneity from HeLa cell extracts. The purified factor can exist in two forms… Expand Familial dysautonomia (FD; also known as "Riley-Day syndrome"), an Ashkenazi Jewish disorder, is the best known and most frequent… Expand ABSTRACT The Elongator complex associated with elongating RNA polymerase II in Saccharomyces cerevisiae was originally reported… Expand Elongator is a histone acetyltransferase complex that associates with the elongating form of RNA polymerase II. We purified… Expand A critical step in the activation of NF-κB is the phosphorylation of IκBs by the IκB kinase (IKK) complex. IKKα and IKKβ are the… Expand One mechanism leading to neurodegeneration during Alzheimer's disease (AD) is amyloid beta peptide (Abeta) neurotoxicity. Abeta… Expand