IGHD1-7 gene

Known as: immunoglobulin heavy diversity 1-7, IGHD1-7, IGHD17 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1979-2017
05010019792017

Papers overview

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Highly Cited
2013
Highly Cited
2013
PURPOSE Trastuzumab emtansine (T-DM1), an antibody-drug conjugate composed of the cytotoxic agent DM1 conjugated to trastuzumab… (More)
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Highly Cited
2012
Highly Cited
2012
Antisense oligonucleotides (ASOs) hold promise for gene-specific knockdown in diseases that involve RNA or protein gain-of… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE Trastuzumab-DM1 (T-DM1) is an antibody-drug conjugate that uses trastuzumab to specifically deliver the maytansinoid… (More)
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Highly Cited
2008
Highly Cited
2008
HER2 is a validated target in breast cancer therapy. Two drugs are currently approved for HER2-positive breast cancer… (More)
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Highly Cited
2007
Highly Cited
2007
The genetic basis of myotonic dystrophy type 1 (DM1) is a CTG expansion in the 3' untranslated region (UTR) of DMPK. The… (More)
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Highly Cited
2005
Highly Cited
2005
Prior studies of the DM1 locus have shown that the CTG repeats are a component of a CTCF-dependent insulator element and that… (More)
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Highly Cited
2002
Highly Cited
2002
Myotonic dystrophy is a complex neuromuscular disorder associated with DNA expansion mutations in two different genes. In DM1 a… (More)
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Highly Cited
2001
Highly Cited
2001
Myotonic dystrophy type 1 (DM1) is caused by a CTG trinucleotide expansion in the 3′ untranslated region of the DM protein kinase… (More)
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Highly Cited
2001
Highly Cited
2001
The phenotypes in myotonic dystrophy types 1 and 2 (DM1 and DM2) are similar, suggesting a shared pathophysiologic mechanism. DM1… (More)
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Highly Cited
2001
Highly Cited
2001
An expansion of a CTG repeat at the DM1 locus causes myotonic dystrophy (DM) by altering the expression of the two adjacent genes… (More)
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