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IGH gene

Known as: Immunoglobulin Heavy Locus, Immunoglobulin Heavy Chain Genes, Immunoglobulin Heavy Chain Locus 
This region represents the germline organization of the immunoglobulin heavy chain locus. The locus includes V (variable), J (joining), diversity (D… 
National Institutes of Health

Related topics

Related topics

9 relations
14q32.33Humoral ImmunityImmune responseImmunoglobulin Gm Allotypes

Broader (1)

Genes, Immunoglobulin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1995
Highly Cited
1995
Routine application of polymerase chain reaction in the diagnosis of monoclonality of B-cell lymphoid proliferations.
We evaluated four polymerase chain reaction (PCR) methods for their efficiency in detecting monoclonality in a well-characterized… 
Highly Cited
1994
Highly Cited
1994
Evidence that the clonogenic cell in multiple myeloma originates from a pre‐switched but somatically mutated B cell
Summary. There is still much controversy about the precursor cell type in multiple myeloma (MM). Some authors claim that it is a… 
Highly Cited
1993
Highly Cited
1993
Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus.
A mutant mouse strain has been generated in which a rearranged immunoglobulin heavy (H) chain variable (V) region gene is placed… 
Highly Cited
1992
Highly Cited
1992
BCL2 oncogene translocation is mediated by a chi-like consensus
Examination of 64 translocations involving the major breakpoint region (mbr) of the BCL2 oncogene and the immunoglobulin heavy… 
Highly Cited
1990
Highly Cited
1990
Two distinct immunoglobulin heavy chain isotypes in a primitive, cartilaginous fish, Raja erinacea.
Immunoglobulin heavy chain genes in Raja erinacea (little skate) are organized in clusters consisting of VH, DH, JH segments and… 
Highly Cited
1989
Highly Cited
1989
Biphenotypic leukemic lymphocyte precursors in CD2+CD19+ acute lymphoblastic leukemia and their putative normal counterparts in human fetal hematopoietic tissues.
During detailed immunophenotypic analyses of marrow blasts from 336 acute lymphoblastic leukemia (ALL) patients, a very small… 
Highly Cited
1986
Highly Cited
1986
During B-cell differentiation enhancer activity and transcription rate of immunoglobulin heavy chain genes are high before mRNA accumulation
Highly Cited
1985
Highly Cited
1985
Fusion of an immunoglobulin variable gene and a T cell receptor constant gene in the chromosome 14 inversion associated with T cell tumors
Highly Cited
1980
Highly Cited
1980
Deletions are associated with somatic rearrangement of immunoglobulin heavy chain genes
Highly Cited
1976
Highly Cited
1976
T-cell idiotypes are linked to immunoglobulin heavy chain genes
FOUR gene clusters have products that seem to participate in antigen binding on T or B lymphocytes. Three (the genes coding for… 
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