IAPP wt Allele

Known as: DAP, Islet Amyloid Polypeptide (Diabetes-Associated Peptide; Amylin) Gene, Islet Amyloid Polypeptide wt Allele 
Human IAPP wild-type allele is located in the vicinity of 12p12.1 and is approximately 25 kb in length. This allele, which encodes islet amyloid… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
The consensus algorithm for the medical management of type 2 diabetes was published in August 2006 with the expectation that it… (More)
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Review
2006
Review
2006
Amylin is a pancreatic B-cell hormone that plays an important role in the regulation of nutrient fluxes. As such, amylin reduces… (More)
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Highly Cited
2000
Highly Cited
2000
Activated microglia surrounding amyloid beta-containing senile plaques synthesize interleukin-1, an inflammatory cytokine that… (More)
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Highly Cited
1997
Highly Cited
1997
Insulin-like growth factors (IGF-I and IGF-II) are well known trophic factors and their specific receptors are uniquely… (More)
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Highly Cited
1996
Highly Cited
1996
Amylin is a 37-amino acid cytotoxic constituent of amyloid deposits found in the islets of Langerhans of patients with type II… (More)
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Highly Cited
1995
Highly Cited
1995
The amyloid beta-peptide (A beta) that accumulates as insoluble plaques in the brains of Alzheimer's victims can be neurotoxic… (More)
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Highly Cited
1995
Highly Cited
1995
Adult male rats were intraperitoneally (i.p.) injected with 1.0 microgram/kg amylin at the beginning of the dark phase in 24 h… (More)
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1991
1991
We examined the in vivo mechanisms of amylin-induced resistance in concious rats (n = 18). During 180-min euglycemic insulin… (More)
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Highly Cited
1990
Highly Cited
1990
Recent interest has focused on the potential role of amylin in the pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM… (More)
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Highly Cited
1988
Highly Cited
1988
Diabetes-associated peptide has recently been isolated and characterized from the amyloid of the islets of Langerhans in type 2… (More)
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