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Hypophysitis

Known as: Hypophysitides, Hypophysitis [Disease/Finding] 
An inflammatory process in the pituitary gland.
National Institutes of Health

Related topics

Related topics

8 relations
In BloodLactotrophsMicrobiologicalPituitary Gland

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
High‐dose glucocorticoids for the treatment of ipilimumab‐induced hypophysitis is associated with reduced survival in patients with melanoma
It remains unclear whether high doses of glucocorticoids have a negative impact on the efficacy of checkpoint inhibitors. To… 
Highly Cited
2016
Highly Cited
2016
Combined nivolumab and ipilimumab versus ipilimumab alone in patients with advanced melanoma: 2-year overall survival outcomes in a multicentre, randomised, controlled, phase 2 trial.
Review
2016
Review
2016
Management of toxicities of immune checkpoint inhibitors.
Highly Cited
2014
Highly Cited
2014
Pituitary Expression of CTLA-4 Mediates Hypophysitis Secondary to Administration of CTLA-4 Blocking Antibody
CTLA-4 blocking antibody induces secondary hypophysitis by binding to CTLA-4 antigen and initiating a type II hypersensitivity… 
Review
2014
Review
2014
Ipilimumab-induced hypophysitis: a detailed longitudinal analysis in a large cohort of patients with metastatic melanoma.
CONTEXT Ipilimumab (Ipi) is approved by the Food and Drug Administration for the treatment of unresectable or metastatic melanoma… 
Review
2012
Review
2012
Management of immune-related adverse events and kinetics of response with ipilimumab.
Monoclonal antibodies directed against the immune checkpoint protein cytotoxic T-lymphocyte antigen-4 (CTLA-4; CD152)-ipilimumab… 
Highly Cited
2012
Highly Cited
2012
Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate…
Highly Cited
2007
Highly Cited
2007
Ipilimumab (Anti-CTLA4 Antibody) Causes Regression of Metastatic Renal Cell Cancer Associated With Enteritis and Hypophysitis
The inhibitory receptor CTLA4 has a key role in peripheral tolerance of T cells for both normal and tumor-associated antigens… 
Highly Cited
2007
Highly Cited
2007
Autoimmune hypophysitis
自身免疫性垂体炎是一种罕见的内分泌疾病,多发生于妊娠或产后.其发病机制不明,临床表现多变,主要包括垂体压迫、腺垂体功能减退症、尿崩症和高催乳素血症等相关症状.治疗目的主要是减小垂体肿块的大小和(或)替代有缺陷的内分泌功能.多数患者需要长期使用激素替代治疗。 
Highly Cited
2003
Highly Cited
2003
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a critical immunoregulatory molecule (expressed on activated T cells and… 
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