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Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy
TLDR
Proton spectroscopy can noninvasively provide useful information on brain tumor type and grade, and quantified lipid, macromolecule, and lactate levels increased with grade of tumor, consistent with progression from hypoxia to necrosis. Expand
Granulation pattern, but not GSP or GHR mutation, is associated with clinical characteristics in somatostatin-naive patients with somatotroph adenomas.
TLDR
Adenoma histological phenotype, not genotype, corresponds to clinical and biochemical characteristics and response to the OST, and SG adenomas constitute a clinically more unfavourable subtype but are not associated with GHR mutations in this series. Expand
Supratentorial and Infratentorial Intraparenchymal Hemorrhage Secondary to Intracranial CSF Hypotension Following Spinal Surgery
TLDR
Intracranial hemorrhage must be considered in the differential diagnosis of patients presenting with persistent headache following spinal surgery when the dura has been breached and is associated with significant cerebrospinal fluid loss. Expand
Subaxial cervical synovial cyst presenting with myelopathy. Report of three cases.
TLDR
The authors report three additional patients treated for degenerative cervical synovial cysts who presented with myelopathy and in all three patients the cyst was successfully excised and a good clinical outcome achieved. Expand
Magnetic resonance neurography studies of the median nerve before and after carpal tunnel decompression.
TLDR
It is suggested that MR neurography is an effective means of both confirming compression of the median nerve and its successful surgical decompression in patients with carpal tunnel syndrome. Expand
What is the natural history of nonoperated nonfunctioning pituitary adenomas?
TLDR
The 'watch and wait' policy seems reasonable for microadenomas but is probably not a safe approach for macroadenomas, which appear to have a significant growth potential; in these cases, given the lack of established medical treatment, the decision for surgical intervention should balance the presence of significant comorbidities and the anaesthetic/peri-operative risks at presentation against the probability of tumour enlargement and its consequences, as well as the possible loss of advantages associated with early operation. Expand
Nonsurgical cerebrospinal fluid rhinorrhea in invasive macroprolactinoma: incidence, radiological, and clinicopathological features.
TLDR
The incidence of nonsurgical CSF rhinorrhea in MPRL patients (8.7%) is higher than expected and dopamine agonist resistance is more common than expected; however, whether this is a mechanistic relationship requires further study. Expand
Outcome of Nonfunctioning Pituitary Adenomas That Regrow After Primary Treatment: A Study From Two Large UK Centers
TLDR
Patients with regrown CNFA after primary treatment continue to carry considerable risk of tumor progression, necessitating long-term follow-up, and a substantial number of patients ultimately required intervention. Expand
Can we ever stop imaging in surgically treated and radiotherapy-naive patients with non-functioning pituitary adenoma?
TLDR
Patients with NFAs need to be closely monitored following surgery, particularly those with post-operative tumour remnants, with 20% of relapse occurring after 10 years, follow-up surveillance needs to be continued beyond this time. Expand
What is the natural history of nonoperated nonfunctioning pituitary adenomas?
TLDR
Results from a series of patients systematically investigating the outcome of clinically nonfunctioning pituitary adenomas not treated by surgery or radiotherapy during long follow‐up periods are unreliable on the assessment of the pros and cons of a ‘watch and wait’ policy. Expand
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