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Hydroxymethylbilane Synthase

Known as: Ammonia-Lyase, Porphobilinogen, Hydroxymethylbilane Synthetase, Porphobilinogen Ammonia Lyase 
An enzyme that catalyzes the tetrapolymerization of the monopyrrole PORPHOBILINOGEN into the hydroxymethylbilane preuroporphyrinogen… 
National Institutes of Health

Related topics

Related topics

14 relations
Acute intermittent porphyriaDisorders of Porphyrin MetabolismHMBS geneIn Blood

Narrower (1)

hemC protein, E coli

Papers overview

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Review
1994
Review
1994
Highlights in haem biosynthesis.
Highly Cited
1994
Highly Cited
1994
Leaf Developmental Age Controls Expression of Genes Encoding Enzymes of Chlorophyll and Heme Biosynthesis in Pea (Pisum sativum L.)
The effects of leaf developmental age on the expression of three nuclear gene families in pea (Pisum sativum L.) coding for… 
Highly Cited
1990
Highly Cited
1990
Molecular basis of hereditary C3 deficiency.
Hereditary deficiency of complement component C3 in a 10-yr-old boy was studied. C3 could not be detected by RIA of serum from… 
Highly Cited
1989
Highly Cited
1989
GATAAG; a cis-control region binding an erythroid-specific nuclear factor with a role in globin and non-globin gene expression.
An erythroid-specific nuclear protein factor binds to a sequence motif (GATAAG) which is present in the promoter region of the… 
Highly Cited
1989
Highly Cited
1989
The mouse porphobilinogen deaminase gene. Structural organization, sequence, and transcriptional analysis.
The porphobilinogen deaminase gene encodes the third enzyme of the heme biosynthetic pathway. This gene is expressed in a tissue… 
Highly Cited
1988
Highly Cited
1988
Activity of porphobilinogen deaminase in peripheral blood mononuclear cells of patients with metastatic cancer
Porphobilinogen deaminase (PBGD), one of the enzymes in the pathway of heme synthesis, was found to be elevated in peripheral… 
Highly Cited
1986
Highly Cited
1986
Nucleotide sequence of the hemC locus encoding porphobilinogen deaminase of Escherichia coli K12.
Porphobilinogen deaminase, the product of the hemC locus in Escherichia coli K12, catalyses the tetrapolymerisation of… 
Highly Cited
1978
Highly Cited
1978
Inhibition of dimethyl sulfoxide-stimulated Friend cell erythrodifferentiation by hydrocortisone and other steroids.
Erythrodifferentiation and hemoglobin synthesis in dimethyl sulfoxide-stimulated Friend erythroleukemia cells were inhibited by… 
Highly Cited
1971
Highly Cited
1971
The serum porphobilinogen and hepatic porphobilinogen deaminase in normal and porphyric individuals.
Abstract Methods are described for quantitative determination of serum PBG and ALA, and for hepatic PBG-D activity. The former… 
Highly Cited
1966
Highly Cited
1966
Activity of Amino-laevulinic Acid Synthetase in Normal and Porphyric Human Livers
ACUTE intermittent porphyria (AIP) is well known as an inborn error of porphyrin metabolism, clinically characterized by attacks… 
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