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Hydroxymethylbilane Synthase

Known as: Ammonia-Lyase, Porphobilinogen, Hydroxymethylbilane Synthetase, Porphobilinogen Ammonia Lyase 
An enzyme that catalyzes the tetrapolymerization of the monopyrrole PORPHOBILINOGEN into the hydroxymethylbilane preuroporphyrinogen… 
National Institutes of Health

Related topics

Related topics

14 relations
Acute intermittent porphyriaDisorders of Porphyrin MetabolismHMBS geneIn Blood

Narrower (1)

hemC protein, E coli

Papers overview

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Highly Cited
2016
Highly Cited
2016
Phase I open label liver-directed gene therapy clinical trial for acute intermittent porphyria.
Highly Cited
2005
Highly Cited
2005
Mosaic origin of the heme biosynthesis pathway in photosynthetic eukaryotes.
Heme biosynthesis represents one of the most essential metabolic pathways in living organisms, providing the precursors for… 
Highly Cited
2000
Highly Cited
2000
Proteins with similar architecture exhibit similar large-scale dynamic behavior.
Highly Cited
2000
Highly Cited
2000
Quantitation of minimal residual disease in acute promyelocytic leukemia patients with t(15;17) translocation using real-time RT-PCR
We took advantage of a recently developed system allowing performance of real-time quantitation of polymerase chain reaction to… 
Highly Cited
2000
Highly Cited
2000
Cell-type Specific Protoporphyrin IX Metabolism in Human Bladder Cancer in vitro¶
Abstract 5-Aminolevulinic acid (ALA)–supported fluorescence endoscopy of the urinary bladder results in a detection rate of… 
Highly Cited
1998
Highly Cited
1998
Biochemical basis of 5-aminolaevulinic acid-induced protoporphyrin IX accumulation: a study in patients with (pre)malignant lesions of the oesophagus.
Administration of 5-aminolaevulinic acid (ALA) leads to porphyrin accumulation in malignant and premalignant tissues, and ALA is… 
Review
1998
Review
1998
Lead poisoning, haem synthesis and 5-aminolaevulinic acid dehydratase.
Highly Cited
1998
Highly Cited
1998
Temperature-stress-induced impairment of chlorophyll biosynthetic reactions in cucumber and wheat
Chlorophyll (Chl) biosynthesis in chill (7 degreesC)- and heat (42 degreesC)-stressed cucumber (Cucumis sativus L. cv poinsette… 
Highly Cited
1997
Highly Cited
1997
Acute intermittent porphyria: prevalence of mutations in the porphobilinogen deaminase gene in blood donors in France
Nordmann Y, Puy H, Da Silva V, Simonin S, Robreau AM, Bonaiti C, Phung LN, Deybach JC (Centre Français des Porphyries, Hopital… 
Highly Cited
1956
Highly Cited
1956
THE OCCURRENCE AND DETERMINATION OF δ-AMINOLEVULINIC ACID AND PORPHOBILINOGEN IN URINE
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