Human mitochondrial molecular clock

The human mitochondrial molecular clock is the rate at which mutations have been accumulating in the mitochondrial genome of hominids during the… (More)
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Highly Cited
2016
Highly Cited
2016
Mitochondrial dysfunction affects cellular energy metabolism, but less is known about the consequences for cytoplasmic… (More)
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Highly Cited
2010
Highly Cited
2010
Solid tumors, including the aggressive primary brain cancer glioblastoma multiforme, develop resistance to cell death, in part as… (More)
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2009
2009
The amyloid-beta 42 (Abeta42) is thought to play a central role in the pathogenesis of Alzheimer's disease (AD). However, the… (More)
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Highly Cited
2008
Highly Cited
2008
Alzheimer's disease (AD) is associated with beta-amyloid accumulation, oxidative stress and mitochondrial dysfunction. However… (More)
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Highly Cited
2006
Highly Cited
2006
  • Kwang-Hyun Baeka, Daniel Z. Skinnera
  • 2006
Reactive oxygen species (ROS) are harmful to living organisms due to the potential oxidation of membranes, DNA, proteins, and… (More)
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Highly Cited
2005
Highly Cited
2005
The 'expanded' HD CAG repeat that causes Huntington's disease (HD) encodes a polyglutamine tract in huntingtin, which first… (More)
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Highly Cited
2004
Highly Cited
2004
Human CYP2J2 is abundant in heart and active in the biosynthesis of epoxyeicosatrienoic acids (EETs); however, the functional… (More)
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Review
2000
Review
2000
Intrasynaptic [glutamate] must be kept low in order to maximize the signal-to-noise ratio after the release of transmitter… (More)
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Highly Cited
1992
Highly Cited
1992
Cytoplasts from two unrelated patients with MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike… (More)
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Highly Cited
1990
Highly Cited
1990
By analysis of a temperature-sensitive yeast mutant, a heat-shock protein in the matrix of mitochondria, mitochondrial hsp70… (More)
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