Human mitochondrial molecular clock

The human mitochondrial molecular clock is the rate at which mutations have been accumulating in the mitochondrial genome of hominids during the… (More)
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5 relations

Broader (2)

Genetic genealogyPhylogenetics
Haplogroup L6 (mtDNA)Molecular clockMost recent common ancestor

Papers overview

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Highly Cited
2016
Highly Cited
2016
Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism.
Mitochondrial dysfunction affects cellular energy metabolism, but less is known about the consequences for cytoplasmic… (More)
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Highly Cited
2010
Highly Cited
2010
Metabolic modulation of glioblastoma with dichloroacetate.
Solid tumors, including the aggressive primary brain cancer glioblastoma multiforme, develop resistance to cell death, in part as… (More)
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2009
2009
Mitochondrial Mislocalization Underlies Aβ42-Induced Neuronal Dysfunction in a Drosophila Model of Alzheimer's Disease
The amyloid-beta 42 (Abeta42) is thought to play a central role in the pathogenesis of Alzheimer's disease (AD). However, the… (More)
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Highly Cited
2008
Highly Cited
2008
A neuronal model of Alzheimer's disease: An insight into the mechanisms of oxidative stress–mediated mitochondrial injury
Alzheimer's disease (AD) is associated with beta-amyloid accumulation, oxidative stress and mitochondrial dysfunction. However… (More)
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Highly Cited
2006
Highly Cited
2006
Alteration of antioxidant enzyme gene expression during cold acclimation of near isogenic wheat lines
  • Kwang-Hyun Baeka, Daniel Z. Skinnera
  • 2006
Reactive oxygen species (ROS) are harmful to living organisms due to the potential oxidation of membranes, DNA, proteins, and… (More)
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Highly Cited
2005
Highly Cited
2005
HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism.
The 'expanded' HD CAG repeat that causes Huntington's disease (HD) encodes a polyglutamine tract in huntingtin, which first… (More)
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Highly Cited
2004
Highly Cited
2004
Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway.
Human CYP2J2 is abundant in heart and active in the biosynthesis of epoxyeicosatrienoic acids (EETs); however, the functional… (More)
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Review
2000
Review
2000
Compartmentation of brain glutamate metabolism in neurons and glia.
Intrasynaptic [glutamate] must be kept low in order to maximize the signal-to-noise ratio after the release of transmitter… (More)
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Highly Cited
1992
Highly Cited
1992
Defects in mitochondrial protein synthesis and respiratory chain activity segregate with the tRNA(Leu(UUR)) mutation associated with mitochondrial myopathy, encephalopathy, lactic acidosis, and…
Cytoplasts from two unrelated patients with MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike… (More)
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Highly Cited
1990
Highly Cited
1990
Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins
By analysis of a temperature-sensitive yeast mutant, a heat-shock protein in the matrix of mitochondria, mitochondrial hsp70… (More)
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