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Human G(i) Alpha Proteins

Known as: G Protein Alpha Inhibiting Polypeptide, G(i) Alpha Protein, Adenylate Cyclase-Inhibiting G Alpha Protein 
Human G(i) Alpha Proteins (G-Alpha 1 Family) are 40-kDa guanine nucleotide-binding alpha protein subunits of heterotrimeric G protein transducers… Expand
National Institutes of Health

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GNAI1 protein, human
GNAZ proteinGuanine Nucleotide-Binding Protein G(o) Subunit AlphaHeterotrimeric GTP-Binding ProteinsSignal Transduction
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Papers overview

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2012
2012
The ligand specificity of the G-protein-coupled receptor GPR34.
Lyso-PS (lyso-phosphatidylserine) has been shown to activate the G(i/o)-protein-coupled receptor GPR34. Since in vitro and in… Expand
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2011
2011
A novel δ opioid receptor‐mediated enhancement of GABAA receptor function induced by stress in ventral tegmental area neurons
Non‐technical summary  Drugs of the opiate class produce analgesia and are addicting. These drugs act at molecular targets called… Expand
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2009
2009
Activation of the histaminergic H3 receptor induces phosphorylation of the Akt/GSK‐3β pathway in cultured cortical neurons and protects against neurotoxic insults
Stimulation of histamine H3 receptors (H3R) activates Gi/o‐proteins that inhibit adenylyl cyclase and triggers MAPK and… Expand
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2009
2009
Signaling pathways involved in DNA synthesis and migration in response to lysophosphatidic acid and low-density lipoprotein in coronary artery smooth muscle cells.
Low-density lipoprotein (LDL) and lysophosphatidic acid (LPA), one of the lipid components of lipoprotein, induced the DNA… Expand
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2003
2003
Extracellular ATP‐induced calcium channel inhibition mediated by P1/P2Y purinoceptors in hamster submandibular ganglion neurons
The presence and profile of purinoceptors in neurons of the hamster submandibular ganglion (SMG) have been studied using the… Expand
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2002
2002
μ-Opioid receptor down-regulation and tolerance are not equally dependent upon G-protein signaling
In the present study, the contribution of pertussis toxin (PTX)-sensitive G(i/o)-proteins to opioid tolerance and mu-opioid… Expand
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2001
2001
Role of G(i)-proteins in norepinephrine-mediated vasoconstriction in rat tail artery smooth muscle.
We showed, in rat de-endothelialised tail artery, that pertussis toxin (PTX) (1 microg/mL, 2 hr) attenuated norepinephrine (NE… Expand
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1998
1998
Differential alterations in left and right ventricular G-proteins in congestive heart failure due to myocardial infarction.
In order to examine the status of G-proteins in congestive heart failure due to myocardial infarction, the left coronary artery… Expand
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Highly Cited
1997
Highly Cited
1997
Inhibition of regulator of G protein signaling function by two mutant RGS4 proteins.
  • K. Druey, J. Kehrl
  • Proceedings of the National Academy of Sciences…
  • 1997
    • Corpus ID: 19189185
Regulators of G protein signaling (RGS) proteins limit the lifetime of activated (GTP-bound) heterotrimeric G protein a subunits… Expand
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1994
1994
Ontogenesis of sympathetic responsiveness in spontaneously hypertensive rats. II. Renal G proteins in male and female rats.
Previously we have reported an increased renal alpha 1- and beta-adrenergic receptor expression in male spontaneously… Expand
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