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Hsp90 Inhibitor HSP990

Known as: HSP990 
An orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor Hsp990 binds to and… 
National Institutes of Health

Related topics

Related topics

1 relation
NCIt Antineoplastic Agent Terminology

Papers overview

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2014
2014
Retraction: Novel HSP90 inhibitor NVP-HSP990 targets cell-cycle regulators to ablate Olig 2-positive glioma tumor-initiating cells.
A University of Texas MD Anderson Cancer Center internal investigation has found that Dr. Jun Fu committed research misconduct as… 
2013
2013
Phase I dose-escalation, open-label study of HSP990 administered orally in adult patients with advanced solid malignancies.
2561^ Background: NVP-HSP990 is a synthetic small molecule that potently and selectively inhibits heat-shock protein 90. HSP990… 
2013
2013
Genotype of proband and thrombophilia screening.
In this issue of Blood , Bucciarelli et al 1 report on the risk for venous thrombosis (VT) among family members of heterozygous… 
2013
2013
HSP90 Inhibition Has Potent Activity Against T-Cell Acute Lymphoblastic Leukemia (T-ALL) Through Degradation Of TYK2 Kinase
The intensification of therapy for patients with T-cell acute lymphoblastic leukemia (T-ALL) has improved clinical outcomes… 
2012
2012
Abstract 5719: Improvement of radiotherapy for glioblastoma by co-targeting PI3K and HSP90
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Introduction: Glioblastoma (GBM) tumors frequently… 
2012
2012
Prostate cancer: Ex vivo efficacy of heat shock protein 90 inhibitors
A study using ex vivo human prostate tumour explants has provided evidence to suggest that heat shock protein 90 (Hsp90) is a… 
2012
2012
Preclinical Development The Novel Oral Hsp 90 Inhibitor NVP-HSP 990 Exhibits Potent and Broad-spectrum Antitumor Activities In Vitro and In Vivo
A novel oral Hsp90 inhibitor, NVP-HSP990, has been developed and characterized in vitro and in vivo. In vitro, NVP-HSP990… 
Review
2011
Review
2011
THE NOVEL ORAL HSP 90 INHIBITOR NVP-HSP 990 EXHIBITS POTENT AND BROAD-SPECTRUM ANTI-TUMOR ACTIVITIES IN VITRO AND IN VIVO
= 176, Text =4987, Figures= 5, Tables= 2, References= 33 on June 23, 2017. © 2012 American Association for Cancer Research. mct… 
2011
2011
HSP90 Inhibition Targets JAK2 and Is Highly Effective in CRLF2-Rearranged Acute Lymphoblastic Leukemia
Abstract 576 Enzymatic inhibitors of Janus kinase 2 (JAK2) are in clinical development for the treatment of B-cell acute… 
2010
2010
61 Evaluation of the synthetic heat shock protein 90 inhibitors NVP-AUY922 and NVP-HSP990 in human prostate cancer tissue
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