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Prostate cancer in a transgenic mouse.
Progress toward understanding the biology of prostate cancer has been slow due to the few animal research models available to study the spectrum of this uniquely human disease. To develop an animalExpand
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Androgen receptor inhibits estrogen receptor-alpha activity and is prognostic in breast cancer.
There is emerging evidence that the balance between estrogen receptor-alpha (ER(alpha)) and androgen receptor (AR) signaling is a critical determinant of growth in the normal and malignant breast. InExpand
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Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1
Breast cancer is a heterogeneous disease and several distinct subtypes exist based on differential gene expression patterns. Molecular apocrine tumours were recently identified as an additionalExpand
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Discovery of circulating microRNAs associated with human prostate cancer using a mouse model of disease
Circulating microRNAs (miRNAs) are emerging as useful non‐invasive markers of disease. The objective of this study was to use a mouse model of prostate cancer as a tool to discover serum miRNAs thatExpand
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Targeting chromatin binding regulation of constitutively active AR variants to overcome prostate cancer resistance to endocrine-based therapies
Androgen receptor (AR) variants (AR-Vs) expressed in prostate cancer (PCa) lack the AR ligand binding domain (LBD) and function as constitutively active transcription factors. AR-V expression inExpand
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Structural and functional consequences of glutamine tract variation in the androgen receptor.
The androgen receptor (AR) gene contains a polymorphic trinucleotide repeat region, (CAG)(n), in its N-terminal transactivation domain (NTD) that encodes a polyglutamine (polyQ) tract in the receptorExpand
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Control of androgen receptor signaling in prostate cancer by the cochaperone small glutamine rich tetratricopeptide repeat containing protein alpha.
Although the androgen receptor (AR) is accepted as the major determinant of prostate cancer cell survival throughout disease progression, it is currently unclear how the receptor sustains genomicExpand
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Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence.
Progression to androgen-independent growth of human prostate cancers may be mediated by alterations in the structure and/or expression of the androgen receptor (AR) gene. To date, mutations in the ARExpand
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Characterization and expression of a cDNA encoding the human androgen receptor.
We report the isolation of a cDNA that encodes the complete human androgen receptor. The cDNA predicts a protein of 917 amino acids with a molecular weight of 98,918. Introduction of the cDNA intoExpand
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Androgens induce divergent proliferative responses in human breast cancer cell lines
Although the majority of primary human breast cancers express the androgen receptor (AR), the role of androgens in breast cancer growth and progression is poorly understood. We have investigated theExpand
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