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Homeobox Prospero-Like Protein PROX1

Known as: PROX1 
Homeobox prospero-like protein PROX1 (737 aa, ~83 kDa) is encoded by the human PROX1 gene. This protein may be involved in transcriptional modulation… Expand
National Institutes of Health

Related topics

Related topics

7 relations
DNA-Binding ProteinsGenes, RegulatorHomeodomain ProteinsPROX1 gene
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Papers overview

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Highly Cited
2010
Highly Cited
2010
Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1.
The concept of inflammation-induced lymphangiogenesis (ie, formation of new lymphatic vessels) has long been recognized, but the… Expand
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Highly Cited
2009
Highly Cited
2009
Prox1 maintains muscle structure and growth in the developing heart
Impaired cardiac muscle growth and aberrant myocyte arrangement underlie congenital heart disease and cardiomyopathy. We show… Expand
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Highly Cited
2008
Highly Cited
2008
Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype.
The Drosophila transcription factor Prospero functions as a tumor suppressor, and it has been suggested that the human… Expand
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Highly Cited
2007
Highly Cited
2007
Bmp and Fgf signaling are essential for liver specification in zebrafish
Based on data from in vitro tissue explant and ex vivo cell/bead implantation experiments, Bmp and Fgf signaling have been… Expand
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Highly Cited
2006
Highly Cited
2006
Expression of Prox1 during mouse cochlear development.
We carried out an analysis of the expression of Prox1, a homeo-domain transcription factor, during mouse inner ear development… Expand
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Highly Cited
2006
Highly Cited
2006
Mesodermal Wnt2b signalling positively regulates liver specification
Endodermal organs such as the lung, liver and pancreas emerge at precise locations along the primitive gut tube. Although several… Expand
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Highly Cited
2006
Highly Cited
2006
A Homeobox Protein, Prox1, Is Involved in the Differentiation, Proliferation, and Prognosis in Hepatocellular Carcinoma
Purpose: It has been shown that a lymphatic differentiation master gene, prox1, also plays an essential role in fetal hepatocyte… Expand
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Highly Cited
2002
Highly Cited
2002
The transcription factor Prox1 is a marker for lymphatic endothelial cells in normal and diseased human tissues.
Detection of lymphatic endothelal cells (LECs) has been problematic because of the lack of specific markers. The homeobox… Expand
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Highly Cited
2001
Highly Cited
2001
The u-boot mutation identifies a Hedgehog-regulated myogenic switch for fiber-type diversification in the zebrafish embryo.
Developmental programs that govern the embryonic diversification of distinct kinds of muscles in vertebrates remain obscure. For… Expand
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Highly Cited
2000
Highly Cited
2000
Hepatocyte migration during liver development requires Prox1
Several genes are required during the early phases of liver specification, proliferation and differentiation. Here we report that… Expand
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