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Genome-scale studies have revealed extensive, cell type-specific colocalization of transcription factors, but the mechanisms… Expand Histone modifications are implicated in influencing gene expression. We have generated high-resolution maps for the genome-wide… Expand Cells employ elaborate mechanisms to introduce structural and chemical variation into chromatin. Here, we focus on one such… Expand Trimethylation of histone H3 at lysine 4 (H3K4me3) is regarded as a hallmark of active human promoters, but it remains unclear… Expand Eukaryotic gene transcription is accompanied by acetylation and methylation of nucleosomes near promoters, but the locations and… Expand Lysine methylation of histones is recognized as an important component of an epigenetic indexing system demarcating… Expand Dynamic regulation of diverse nuclear processes is intimately linked to covalent modifications of chromatin. Much attention has… Expand We mapped histone H3 lysine 4 di- and trimethylation and lysine 9/14 acetylation across the nonrepetitive portions of human… Expand Lysine residues within histones can be mono-, di - or tri-methylated. In Saccharomyces cerevisiae tri-methylation of Lys 4 of… Expand Posttranslational modifications of histone N-terminal tails impact chromatin structure and gene transcription. While the extent… Expand