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Hirulog-1

National Institutes of Health

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Broader (1)

bivalirudin

Papers overview

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2001
2001
Hirulog-Like Peptide Reduces Balloon Catheter Injury Induced Neointima Formation in Rat Carotid Artery without Increase in Bleeding Tendency
Abstract: Vascular restenosis is one of the major concerns for the management of coronary artery disease using therapeutic… 
2000
2000
Hirulog-1 Reduces Expression of Platelet-Derived Growth Factor in Neointima of Rat Carotid ArteryInduced by Balloon Catheter Injury
Vascular restenosis is one of the major concerns for the treatment of atherosclerotic cardiovascular diseases using therapeutic… 
2000
2000
New bivalent thrombin inhibitors with N(alpha)(methyl)arginine at the P1-position.
A series of bivalent thrombin inhibitors was synthesized, consisting of a d-phenylalanyl-prolyl-N(alpha)(methyl)arginyl active… 
1998
1998
Transcellular Signaling and Pharmacological Modulation of Thrombin-Induced Production of Plasminogen Activator Inhibitor-1 in Vascular Smooth Muscle Cells
Thrombin formation is increased at the sites of vascular injury. Previous studies by our group and other groups indicated that… 
1997
1997
Inhibition by hirulog-1 of generation of plasminogen activator inhibitor-1 from vascular smooth-muscle cells induced by thrombin.
Hirulog-1 effectively prevents thrombosis in coronary artery disease and is associated with a low incidence of bleeding… 
1997
1997
2.P.376 Effect of hirulog-1 on fibrinolysis and platelet deposition
1996
1996
Anticoagulant peptides; synthesis, stability and antithrombin activity of hirudin C-terminal-related peptides and their disulfated analog.
We designed a unique anticoagulant decapeptide, which possesses two O-sulfated tyrosine residues, based on the structure of… 
1993
1993
The Effect of Antithrombin III-Independent Thrombin Inhibitors and Heparin on Fibrin Accretion onto Fibrin-Coated Polyethylene
Summary Prosthetic vascular grafts become coated with a layer of fibrin that contributes to graft thrombosis and occlusion. We… 
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