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Hirschsprung Disease

Known as: disease hirschsprung, MEGACOLON, CONGENITAL, Hirschsprung's Disease 
Congenital MEGACOLON resulting from the absence of ganglion cells (aganglionosis) in a distal segment of the LARGE INTESTINE. The aganglionic segment… 
National Institutes of Health

Related topics

Related topics

42 relations
Acquired megacolonCartilage-hair hypoplasiaColon structure (body structure)Congenital Digestive System Disorder

Narrower (10)

Aganglionosis, Rectosigmoid ColonAl Gazali Hirschsprung syndromeCongenital Intestinal AganglionosisGoldberg-Shprintzen megacolon syndrome

Broader (6)

Colonic DiseasesCongenital DisordersCongenital digestive system anomaliesFetal Diseases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Functional haplotypes of the RET proto-oncogene promoter are associated with Hirschsprung disease (HSCR).
The activation of the RET signaling pathway during embryogenesis is a crucial prerequisite for a directional migration of enteric… 
Review
2001
Review
2001
Intestinal Motility Disorders and Development of the Enteric Nervous System
The enteric nervous system (ENS) is an independent nervous system. It contains as many neurons as the spinal cord, every class of… 
Highly Cited
1997
Highly Cited
1997
Intestinal pacemaker C-KIT+ cells and synapses in allied Hirschsprung's disorders.
Review
1993
Review
1993
Total parenteral nutrition-associated cholestasis: clinical and histopathologic correlation.
Highly Cited
1975
Highly Cited
1975
Demonstration of a nonadrenergic inhibitory nervous system in the trachea of the guinea pig.
Highly Cited
1969
Highly Cited
1969
Adrenergic Innervation of Bowel in Hirschsprung's Disease
The adrenergic innervation of normal and aganglionic regions of bowel from patients with Hirschsprung's disease was investigated… 
Highly Cited
1968
Highly Cited
1968
Adrenergic myenteric nerves in Hirschsprung's disease.
Effect of Peritoneal Diadysis.-In two patients carbenicillin was administered during peritoneal dialysis and the serum levels and… 
Highly Cited
1967
Highly Cited
1967
Differential sphincteric studies in the diagnosis of ano-rectal disorders of childhood.
Highly Cited
1966
Highly Cited
1966
Rectal myectomy for aganglionic megacolon.
Highly Cited
1961
Highly Cited
1961
Effects of destruction of intramural ganglion cells on colon motility: possible genesis of congenital megacolon.
1. In the dog, a segment of colon corresponding to the recto-sigmoid region of man, was kept in a temporary state of anemia by… 
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