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Hereditary factor II deficiency disease

Known as: Hereditary Prothrombin Deficiency, Hereditary Factor II Deficiency, DYSPROTHROMBINEMIA 
A very rare autosomal recessive inherited blood coagulation disorder characterized by deficiency of prothrombin, resulting in bleeding.
National Institutes of Health

Papers overview

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Review
2013
Review
2013
Prothrombin (factor II [FII]) deficiency is a rare inherited coagulation disorder, having a prevalence of approximately 1 in 2… Expand
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2013
2013
Prothrombin, the precursor to thrombin, is a serine protease that plays a key role in hemostasis and thrombosis. Several studies… Expand
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Review
2009
Review
2009
Prothrombin deficiency is among the rarest inherited coagulation disorders, with a prevalence of approximately 1:2,000,000. Two… Expand
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2003
2003
Five unrelated families with Puerto Rican ancestry were identified as having at least one member with bleeding due to a… Expand
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2001
2001
Several members of a family from Scranton, Pennsylvania were identified to have normal levels of prothrombin antigen while their… Expand
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2000
2000
Prothrombin deficiency is an autosomal recessive disorder associated with a moderately severe bleeding tendency. In this study… Expand
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Review
1998
Review
1998
Prothrombin (factor II) deficiency was first described in 1947 by Quick et al., although the first prothrombin abnormality was… Expand
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1992
1992
The molecular and genetic basis of a compound heterozygote for dys- and hypoprothrombinemia was analyzed. Abnormal nucleotide… Expand
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1974
1974
Abstract A new congenital dysprothrombinemia is presented. The propositus is a 7-year-old boy who was noted to bleed excessively… Expand
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1969
1969
A large family has been studied, 11 of whose members have half-normal plasma concentrations of biological prothrombin activity… Expand
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