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Hemospan

Known as: Hemospan PS 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

maleimide-polyethylene glycol-modified hemoglobin, MP4

Papers overview

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Highly Cited
2009
Highly Cited
2009
Hemospan: design principles for a new class of oxygen therapeutic.
Hemoglobin-based oxygen carriers have been under development for decades, but safety concerns have prevented commercial approval… 
Highly Cited
2009
Highly Cited
2009
PEGylation promotes hemoglobin tetramer dissociation.
Hemoglobin conjugated with poly(ethylene glycol) (PEG) acts as an oxygen carrier free in plasma, substituting red blood cells in… 
2009
2009
Hemospan improves outcome in a model of perioperative hemodilution and blood loss in the rat: comparison with hydroxyethyl starch.
OBJECTIVES Hemospan (Sangart Inc, San Diego, CA) (MP4) is a hemoglobin-based oxygen carrier consisting of human hemoglobin… 
2008
2008
Sites of modification of hemospan, a poly(ethylene glycol)-modified human hemoglobin for use as an oxygen therapeutic.
Hemospan is an acellular hemoglobin-based oxygen therapeutic in clinical trials in Europe and the United States. The product is… 
Highly Cited
2008
Highly Cited
2008
CO‐MP4, a polyethylene glycol‐conjugated haemoglobin derivative and carbon monoxide carrier that reduces myocardial infarct size in rats
MP4 (Hemospan) is a Hb‐based oxygen therapeutic agent, based on polyethylene‐glycol (PEG) conjugation to Hb, undergoing clinical… 
Review
2008
Review
2008
Hemospan: a hemoglobin-based oxygen carrier for potential use as a blood substitute and for the potential treatment of critical limb ischemia.
Hemospan, a novel hemoglobin-based oxygen carrier and plasma expander, is being developed by Sangart Inc for use as a blood… 
Highly Cited
2007
Highly Cited
2007
Toxicity and hemodynamic effects after single dose administration of MalPEG-hemoglobin (MP4) in rhesus monkeys.
Review
2007
Review
2007
Blood substitutes as pharmacotherapies in clinical practice
Purpose of review To discuss the development and current status of blood substitutes, including hemoglobin-based oxygen carriers… 
Highly Cited
2006
Highly Cited
2006
A Multicenter Clinical Study of the Safety and Activity of Maleimide-Polyethylene Glycol–modified Hemoglobin (Hemospan®) in Patients Undergoing Major Orthopedic Surgery
Background:Hemospan® (Sangart Inc., San Diego, CA), a polyethylene glycol–modified hemoglobin with unique oxygen transport… 
Highly Cited
2005
Highly Cited
2005
A phase I single blind clinical trial of a new oxygen transport agent (MP4), human hemoglobin modified with maleimide-activated polyethylene glycol.
BACKGROUND AND OBJECTIVES MP4 (Hemospan), a hemoglobin-based oxygen carrier, has been designed to deliver oxygen to hypoxic… 
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