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Heme Oxygenase-1

Known as: Heme Oxygenase-1 [Chemical/Ingredient], Oxygenase-1, Heme, HMOX1 
A ubiquitous stress-responsive enzyme that catalyzes the oxidative cleavage of HEME to yield IRON; CARBON MONOXIDE; and BILIVERDIN.
National Institutes of Health

Papers overview

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Review
2010
Review
2010
Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe(2+), carbon… Expand
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Highly Cited
2002
Highly Cited
2002
The mechanisms underlying the action of the potent anti-inflammatory interleukin-10 (IL-10) are poorly understood. Here we show… Expand
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Highly Cited
2000
Highly Cited
2000
Heme oxygenase 1 (HO-1) inhibits apoptosis by regulating cellular prooxidant iron. We now show that there is an additional… Expand
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Highly Cited
2000
Highly Cited
2000
Curcumin, a widely used spice and coloring agent in food, has been shown to possess potent antioxidant, antitumor promoting and… Expand
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Highly Cited
1999
Highly Cited
1999
The first known human case of heme oxygenase-1 (HO-1) deficiency is presented in this report. The patient is a six-year-old boy… Expand
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Highly Cited
1999
Highly Cited
1999
Stress response elements, which mediate induction of the mouse heme oxygenase-1 (HO-1) gene by several agents, resemble the… Expand
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Highly Cited
1997
Highly Cited
1997
  • K. Poss, S. Tonegawa
  • Proceedings of the National Academy of Sciences…
  • 1997
  • Corpus ID: 1884061
Stressed mammalian cells up-regulate heme oxygenase 1 (Hmox1; EC 1.14.99.3), which catabolizes heme to biliverdin, carbon… Expand
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Highly Cited
1997
Highly Cited
1997
  • K. Poss, S. Tonegawa
  • Proceedings of the National Academy of Sciences…
  • 1997
  • Corpus ID: 16215084
The majority of iron for essential mammalian biological activities such as erythropoiesis is thought to be reutilized from… Expand
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Highly Cited
1997
Highly Cited
1997
Exposure of rats to hypoxia (7% O2) markedly increased the level of heme oxygenase-1 (HO-1) mRNA in several tissues. Accumulation… Expand
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Highly Cited
1996
Highly Cited
1996
Chronic inflammatory diseases place a heavy social and economic burden on the resources of many nations, but the number of safe… Expand
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