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Heme Oxygenase-1

Known as: Heme Oxygenase-1 [Chemical/Ingredient], Oxygenase-1, Heme, HMOX1 
A ubiquitous stress-responsive enzyme that catalyzes the oxidative cleavage of HEME to yield IRON; CARBON MONOXIDE; and BILIVERDIN.
National Institutes of Health

Related topics

Related topics

19 relations
Catabolic ProcessEnzyme GeneHMOX1 geneHMOX1 wt Allele

Narrower (3)

HMOX1 protein, humanHmox1 protein, mousePEP-1-heme oxygenase-1 fusion protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury
Renal ischemia-reperfusion injury (IRI) is a major risk factor for delayed graft function in renal transplantation. Compelling… 
2008
2008
X-ray crystal structure of human heme oxygenase-1 in complex with 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone: a common binding mode for imidazole-based heme oxygenase-1 inhibitors.
Development of inhibitors specific for heme oxygenases (HOs) should aid our understanding of the HO system and facilitate future… 
Highly Cited
2007
Highly Cited
2007
Heme Oxygenase-1 Induction by the Clinically Used Anesthetic Isoflurane Protects Rat Livers From Ischemia/Reperfusion Injury
Objective:It was the aim of this study to characterize the influence of isoflurane-induced heme oxygenase-1 (HO-1) expression on… 
Highly Cited
2004
Highly Cited
2004
15-Deoxy-Δ12,14-prostaglandin J2 Induces Heme Oxygenase-1 Gene Expression in a Reactive Oxygen Species-dependent Manner in Human Lymphocytes*
15-Deoxy-Δ12,14-prostaglandin J2 (15dPGJ2 has been recently proposed as a potent anti-inflammatory agent. However, the mechanisms… 
Highly Cited
2003
Highly Cited
2003
Bilirubin rinse: A simple protectant against the rat liver graft injury mimicking heme oxygenase–1 preconditioning
Heme oxygenase (HO)‐1 preconditioning through genetic or pharmacologic interventions was shown experimentally to improve… 
Highly Cited
2003
Highly Cited
2003
Systemic Rather Than Local Heme Oxygenase-1 Overexpression Improves Cardiac Allograft Outcomes in a New Transgenic Mouse1
Heme oxygenase-1 (HO-1), a rate-limiting enzyme in heme catabolism, exhibits potent antioxidant and anti-inflammatory properties… 
Highly Cited
1999
Highly Cited
1999
Increased heme oxygenase‐1 gene expression in liver cells and splanchnic organs from portal hypertensive rats
Heme oxygenase (HO) catalyzes the conversion of heme into biliverdin, iron, and carbon monoxide (CO). Two isoforms of HO have… 
Highly Cited
1998
Highly Cited
1998
Lung-specific induction of heme oxygenase-1 and hyperoxic lung injury.
Heme oxygenase (HO)-1, which catalyzes heme breakdown, is induced by oxidative stress and may protect against oxidative injury… 
Highly Cited
1997
Highly Cited
1997
Induction of Heme Oxygenase-1 Expression in Vascular Smooth Muscle Cells
Endotoxic shock is a life-threatening consequence of severe Gram-negative infection characterized by vascular smooth muscle cell… 
Highly Cited
1995
Highly Cited
1995
Heme Oxygenase-2
Recombinant human microsomal heme oxygenase-2 was expressed in Escherichia coli. Tryptic digestion of the membrane fraction, in… 
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