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Anti-drug antibodies to coagulation factor VIII (fVIII), often termed inhibitors, present the greatest economical and treatment… Expand

Essentials Factor VIII inhibitors are the most serious complication in patients with hemophilia A. Aggregates in… Expand

Hemophilia A is a X-linked recessive bleeding disorder consecutive to the lack of circulating pro-coagulant factor VIII (FVIII… Expand

The administration of therapeutic factor VIII (FVIII) to treat or prevent haemorrhages in haemophilia A patients results, in up… Expand

patient decide. Inhibitor formation is a multicausal process and FVIII exposure is undeniably a necessary cause of inhibitors… Expand

The state-of-the-art treatment for hemophilia A is replacement therapy with recombinant factor VIII (rFVIII) made possible by… Expand

Recombinant hirudin (rH) is a highly specific thrombin inhibitor which is under clinical investigation for various thrombotic… Expand