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HUS1 gene

Known as: HUS1 checkpoint clamp component, HYDROXYUREA-SENSITIVE 1, S. POMBE, HOMOLOG OF, HUS1 
National Institutes of Health

Papers overview

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2012
2012
Heat induction of a novel Rad9 variant from a cryptic translation initiation site reduces mitotic commitment
Summary Exposure of human cells to heat switches the activating signal of the DNA damage checkpoint from genotoxic to temperature… 
2009
2009
Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study.
2007
2007
Genome Maintenance Defects in Cultured Cells and Mice following Partial Inactivation of the Essential Cell Cycle Checkpoint Gene Hus1
ABSTRACT Cell cycle checkpoints are evolutionarily conserved signaling pathways that uphold genomic integrity. Complete… 
2007
2007
An essential role for Drosophila hus1 in somatic and meiotic DNA damage responses
The checkpoint proteins Rad9, Rad1 and Hus1 form a clamp-like complex which plays a central role in the DNA-damage-induced… 
2006
2006
Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus.
The DNA damage checkpoint pathways sense and respond to DNA damage to ensure genomic stability. The ATR kinase is a central… 
Highly Cited
2003
Highly Cited
2003
Critical Role for Mouse Hus1 in an S-Phase DNA Damage Cell Cycle Checkpoint
ABSTRACT Mouse Hus1 encodes an evolutionarily conserved DNA damage response protein. In this study we examined how targeted… 
2003
2003
Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene.
2002
2002
Downregulation of Hus1 by antisense oligonucleotides enhances the sensitivity of human lung carcinoma cells to cisplatin
In Schizosaccharomyces pombe, Hus1 is a component of the radiation sensitive (Rad) machinery that has been identified as playing… 
Highly Cited
2000
Highly Cited
2000
Inactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stress.
The eukaryotic cell cycle is overseen by regulatory mechanisms, termed checkpoints, that respond to DNA damage, mitotic spindle… 
1999
1999
Mouse Hus1, a homolog of the Schizosaccharomyces pombe hus1+ cell cycle checkpoint gene.
Cell cycle checkpoints are regulatory mechanisms that arrest the cell cycle or initiate programmed cell death when critical… 
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