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HUS1 gene

Known as: HUS1 checkpoint clamp component, HYDROXYUREA-SENSITIVE 1, S. POMBE, HOMOLOG OF, HUS1 
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
A subset of ATM‐ and ATR‐dependent phosphorylation events requires the BRCA1 protein
BRCA1 is a central component of the DNA damage response mechanism and defects in BRCA1 confer sensitivity to a broad range of DNA… 
Highly Cited
2003
Highly Cited
2003
Checkpoint activation regulates mutagenic translesion synthesis.
Cells have evolved checkpoint responses to arrest or delay the cell cycle, activate DNA repair networks, or induce apoptosis… 
Highly Cited
2003
Highly Cited
2003
Regulation of Chk1 Includes Chromatin Association and 14-3-3 Binding following Phosphorylation on Ser-345*
Checkpoints are biochemical pathways that provide the cell with mechanisms to detect DNA damage and respond by arresting the cell… 
Highly Cited
2002
Highly Cited
2002
A DNA Damage-Regulated BRCT-Containing Protein, TopBP1, Is Required for Cell Survival
ABSTRACT BRCA1 carboxyl-terminal (BRCT) motifs are present in a number of proteins involved in DNA repair and/or DNA damage… 
Highly Cited
2001
Highly Cited
2001
Reconstitution and Molecular Analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA Damage Responsive Checkpoint Complex*
DNA damage activates cell cycle checkpoint signaling pathways that coordinate cell cycle arrest and DNA repair. Three of the… 
Highly Cited
2000
Highly Cited
2000
Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes
The repair of damaged DNA is coupled to the completion of DNA replication by several cell cycle checkpoint proteins, including… 
Highly Cited
2000
Highly Cited
2000
Characterization of Schizosaccharomyces pombeHus1: a PCNA-Related Protein That Associates with Rad1 and Rad9
ABSTRACT Hus1 is one of six checkpoint Rad proteins required for allSchizosaccharomyces pombe DNA integrity checkpoints. MYC… 
Highly Cited
2000
Highly Cited
2000
Inactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stress.
The eukaryotic cell cycle is overseen by regulatory mechanisms, termed checkpoints, that respond to DNA damage, mitotic spindle… 
Highly Cited
1999
Highly Cited
1999
The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1.
Eukaryotic cells actively block entry into mitosis in the presence of DNA damage or incompletely replicated DNA. This response is… 
Highly Cited
1999
Highly Cited
1999
Human Homologs of Schizosaccharomyces pombe Rad1, Hus1, and Rad9 Form a DNA Damage-responsive Protein Complex*
DNA damage activates cell cycle checkpoints in yeast and human cells. In the yeasts Saccharomyces cerevisiae and… 
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