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HTRA2 gene

Known as: PRSS25, HtrA serine peptidase 2, HTRA, E. COLI, HOMOLOG OF, 2 
National Institutes of Health

Related topics

Related topics

2 relations
Omi serine proteaseParkinson Disease 13

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2.
The protease HtrA2 has a protective role inside mitochondria, but promotes apoptosis under stress. We previously identified the… 
2016
2016
HtrA2 suppresses autoimmune arthritis and regulates activation of STAT3
Rheumatoid arthritis (RA) is an autoimmune disease that is related to the induction of T helper (Th)17 cells, which secrete… 
2013
2013
The member of high temperature requirement family HtrA2 participates in neuronal apoptosis after intracerebral hemorrhage in adult rats
The members of high-temperature requirement (HtrA) family are evolutionarily conserved serine proteases that combine a trypsin… 
2012
2012
The Protease Omi Cleaves the Mitogen-Activated Protein Kinase Kinase MEK1 to Inhibit Microglial Activation
Loss of a protease in microglia results in neuroinflammation that contributes to neurodegeneration and Parkinson’s disease. Omi… 
2012
2012
Targeting Multidrug Resistant Mycobacterium tuberculosis HtrA2 with Identical Chemical Entities of Fluoroquinolones
Tuberculosis is a highly communicable and chronic respiratory disease caused by pathogenic bacterium Mycobacterium tuberculosis… 
2010
2010
Omi/HtrA2 protease is associated with tubular cell apoptosis and fibrosis induced by unilateral ureteral obstruction.
Kidney fibrosis, a typical characteristic of chronic renal disease, is associated with tubular epithelial cell apoptosis. The… 
2009
2009
Omi is a mammalian heat-shock protein that selectively binds and detoxifies oligomeric amyloid-β
The cellular generation of toxic metabolites and subsequent detoxification failure can cause the uncontrolled accumulation of… 
2007
2007
Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation
The serine protease Omi/HtrA2 was initially regarded as a proapoptotic molecule that proteolyses several proteins to induce cell… 
2007
2007
Mitochondrial import of Omi: the definitive role of the putative transmembrane region and multiple processing sites in the amino-terminal segment.
Highly Cited
2005
Highly Cited
2005
HtrA2 cleaves Apollon and induces cell death by IAP-binding motif in Apollon-deficient cells.
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