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This study was performed to characterize the protonation equilibrium at the molecular level and pH-dependent lipophilicity of… Expand ABSTRACT We examined the antimicrobial susceptibilities of 85Neisseria gonorrhoeae isolates, classified according to the presence… Expand ABSTRACT We compared the in vitro antimycobacterial activity of a new fluoroquinolone, HSR-903, with strong activity against gram… Expand The distribution of HSR-903, a new quinolone antibacterial agent, to the brain after i.v. administration to rats was low compared… Expand HSR-903 [(S)-(-)-5-amino-7-(7-amino-5-azaspiro[2. 4]hept-5-yl)-1-cyclopropyl-6-fluoro-1, 4-dihydro-8-methyl-4-oxoquinoline-3… Expand ABSTRACT The in vitro activity of HSR-903, an oral quinolone, against 196 recent clinical isolates of respiratory pathogens was… Expand HSR-903 is a newly synthesized quinolone antibacterial agent with low toxicity. The biliary and urinary excretion of unchanged… Expand ABSTRACT The in vivo activity of HSR-903, a new fluoroquinolone, against major bacteria which cause respiratory tract infections… Expand The in vitro activity of the new fluoroquinolone HSR-903 was compared with those of ciprofloxacin, lomefloxacin, sparfloxacin… Expand The in vitro and in vivo antichlamydial activities of HSR-903 were investigated. The MICs of HSR-903 for different species of… Expand