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HSPA9 gene

Known as: MOT2, GRP75, HSPA9B 
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis.
The mitochondrial chaperone mortalin has been linked to neurodegeneration in Parkinson's disease (PD) based on reduced protein… 
Review
2007
Review
2007
Three faces of mortalin: A housekeeper, guardian and killer
Highly Cited
2006
Highly Cited
2006
Proteomic Identification of a Stress Protein, Mortalin/mthsp70/GRP75
Functional impairment of mitochondria and proteasomes and increased oxidative damage comprise the main pathological phenotypes of… 
Highly Cited
2006
Highly Cited
2006
Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis
Mortalin, also known as mthsp70/GRP75/PBP74, interacts with the tumor suppressor protein p53 and inactivates its transcriptional… 
Highly Cited
2005
Highly Cited
2005
Mortalin is over‐expressed by colorectal adenocarcinomas and correlates with poor survival
Using comparative proteomic analysis we have identified over‐expression of mortalin in colorectal adenocarcinomas. Mortalin, also… 
Highly Cited
2005
Highly Cited
2005
Activation of Wild Type p53 Function by Its Mortalin-binding, Cytoplasmically Localizing Carboxyl Terminus Peptides*
The Hsp70 family member mortalin (mot-2/mthsp70/GRP75) binds to a carboxyl terminus region of the tumor suppressor protein p53… 
Highly Cited
2004
Highly Cited
2004
Proteomic identification of specific oxidized proteins in ApoE-knockout mice: relevance to Alzheimer's disease.
Highly Cited
2000
Highly Cited
2000
Extramitochondrial localization of mortalin/mthsp70/PBP74/GRP75.
Subcellular fractionation and immunofluorescence microscopy were used to identify the specific sites of intracellular residence… 
Highly Cited
1999
Highly Cited
1999
5-Bromodeoxyuridine induces senescence-like phenomena in mammalian cells regardless of cell type or species.
5-Bromodeoxyuridine was found to induce flat and enlarged cell shape, characteristics of senescent cells, and senescence… 
Highly Cited
1998
Highly Cited
1998
Inactivation of Tumor Suppressor p53 by Mot-2, a hsp70 Family Member*
The mortalin genes, mot-1 andmot-2, are hsp70 family members that were originally cloned from normal and immortal murine cells… 
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