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HPE 101

Known as: HPE-101 
 
National Institutes of Health

Papers overview

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2010
2010
Possibility and effectiveness of drug delivery to skin by needle-free injector.
We evaluated a needle-free injector (NFI), which has been studied as an administration device to the subcutaneous tissue, as a… Expand
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2007
2007
Preclinical Investigation of the Topical Administration of Phenserine: Transdermal Flux, Cholinesterase Inhibition, and Cognitive Efficacy
Phenserine (PS) was designed as a selective acetylcholinesterase (AChE) inhibitor, with a tartrate form (PST) for oral… Expand
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2006
2006
The effect of skin permeation enhancers on the formation of porphyrins in mouse skin during topical application of the methyl ester of 5-aminolevulinic acid.
The influence of skin permeation enhancers, such as dimethyl sulphoxide (DMSO) and 1-[2-(decylthio)ethyl]azacyclopentan-2-one… Expand
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2004
2004
Application of in Vivo Microdialysis to Transdermal Absorption of Methotrexate in Rats
Microdialysis was applied to determine the in vivo transdermal absorption of methotrexate (MTX) in rats with or without a new… Expand
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1996
1996
Evaluation of In‐vivo Transdermal Absorption of Cyclosporin with Absorption Enhancer Using Intradermal Microdialysis in Rats
The purpose of this study was to evaluate the effect of absorption enhancer on in‐vivo transdermal absorption of cyclosporin… Expand
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1994
1994
In vivo microdialysis for the transdermal absorption of valproate in rats.
The suitability of sampling via microdialysis for a lipophilic drug, valproate (VPA), was evaluated by the elimination rate… Expand
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1993
1993
Further Evaluation of a New Penetration Enhancer, HPE‐101
Abstract— The penetration enhancer, 1‐[2‐(decylthio)ethyl]azacyclopentan‐2‐one (HPE‐101), significantly enhanced the excretion of… Expand
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1992
1992
Evaluation of a new penetration enhancer 1-[2-(decylthio)ethyl]azacyclopentan-2-one (HPE-101).
A new compound, 1-[2-(decylthio)ethyl]azacyclopentan-2-one (HPE-101) was synthesized, and its skin penetration enhancing activity… Expand
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1992
1992
Inhibitory effect of prostaglandin E1 on laurate-induced peripheral vascular occlusive sequelae in rabbits: optimized topical formulation with beta-cyclodextrin derivative and penetration enhancer…
Prostaglandin E1 (PGE1) and its inclusion complexes with beta-cyclodextrin (beta-CyD) and O-carboxymethyl-O-ethyl-beta… Expand
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1992
1992
Improved transdermal delivery of prostaglandin E1 through hairless mouse skin: combined use of carboxymethyl‐ethyl‐β‐cyclodextrin and penetration enhancers
Abstract— The optimal prescription of transdermal preparations of prostaglandin E1 (PGE1) for treatment of peripheral vascular… Expand
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