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HMR 1766

Known as: HMR-1766, HMR1766 
National Institutes of Health

Papers overview

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Review
2010
Review
2010
Exploring the potential of NO-independent stimulators and activators of soluble guanylate cyclase for the medical treatment of erectile dysfunction.
Nitric oxide (NO)-sensitive soluble guanylyl cyclase (sGC) is the receptor that catalyzes the formation of the intracellular… 
2009
2009
Stimulation of cGMP signalling protects coronary endothelium against reperfusion-induced intercellular gap formation.
AIMS Ischaemia-reperfusion provokes barrier failure of the coronary microvasculature, impeding functional recovery of the heart… 
2008
2008
Zum Einfluss desStickstoffmonoxid (NO) Systems auf die Hyperoxie-induziertepostnatale Lungenreifungsstörung
Trotz der grosen Fortschritte in der Peri- und Neonatologie stellt die bronchopulmonale Dysplasie (BPD) 40 Jahre nach ihrer… 
2007
2007
Significant Pharmacokinetic and Pharmacodynamic Interaction of Warfarin With the NO‐Independent sGC Activator HMR1766
HMR1766 is a new nitric oxide (NO)–independent activator of soluble guanylyl cyclase (sGC) in development for the treatment of… 
2007
2007
Activation of soluble guanylyl cyclase (sGC) by the NO/heme-independent activator HMR1766 in cells
Most vascular diseases are characterized by an increase in the production of reactive oxygen species (ROS). The resulting… 
2006
2006
Soluble Guanylyl Cyclase Activation With HMR1766 Attenuates Platelet Activation in Diabetic Rats
Objective— Platelet activation significantly contributes to cardiovascular morbidity and mortality in diabetes. An association… 
2006
2006
Abstract 1460: Effect of HMR1766, a Soluble Guanylate Cyclase Activator, on Differentiation of Cardiac Fibroblasts and Extracellular Matrix Synthesis Induced by TGFbeta
2005
2005
Role of activators of ferric sGC in cardiovascular disease
Soluble guanylyl cyclase (sGC), the key transducer of nitric oxide (NO) signalling in vascular smooth muscle cells and platelets… 
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