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HMPL-013

Known as: VEGFR-1/2/3 Inhibitor HMPL-013 
 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

BenzofuransQuinazolines

Narrower (1)

fruquintinib

Papers overview

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Review
2019
Review
2019
The clinical application of fruquintinib on colorectal cancer
ABSTRACT Introduction: Anti-angiogenetic agents are currently the most commonly used drugs for the treatment of colorectal cancer… Expand
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2017
2017
A phase I study to investigate the metabolism, excretion, and pharmacokinetics of [14C]fruquintinib, a novel oral selective VEGFR inhibitor, in healthy Chinese male volunteers
PurposeFruquintinib (HMPL-013) is a novel, potent, and highly selective tyrosine kinase inhibitor targeting the vascular… Expand
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2016
2016
A Phase I study of safety and pharmacokinetics of fruquintinib, a novel selective inhibitor of vascular endothelial growth factor receptor-1, -2, and -3 tyrosine kinases in Chinese patients with…
PurposeFruquintinib (HMPL-013) is a novel oral small molecule compound that selectively inhibits vascular endothelial growth… Expand
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2014
2014
Preclinical pharmacokinetics and disposition of a novel selective VEGFR inhibitor Fruquintinib (HMPL-013) and the prediction of its human pharmacokinetics
AbstractPurpose This study evaluated the preclinical pharmacokinetics (PK) and disposition of Fruquintinib (HMPL-013), a small… Expand
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2014
2014
Discovery of fruquintinib, a potent and highly selective small molecule inhibitor of VEGFR 1, 2, 3 tyrosine kinases for cancer therapy.
VEGF/VEGFR signal axis has been proven to be an important target for development of novel cancer therapies. One challenging… Expand
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