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HMI-1a3

National Institutes of Health

Papers overview

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2018
2018
Anticancer activity of the protein kinase C modulator HMI‐1a3 in 2D and 3D cell culture models of androgen‐responsive and androgen‐unresponsive prostate cancer
Prostate cancer is one of the most common cancers in men. Although it has a relatively high 5‐year survival rate, development of… 
2016
2016
C 1 domain-targeted isophthalates as protein kinase C modulators : Structure-based design , structure-activity relationships and biological activities
  • 2016
  • Corpus ID: 12140861
Protein kinase C (PKC) is a serine/threonine kinase belonging to the AGC family. PKC isoenzymes are activated by phospholipid… 
2014
2014
Evidence for a role of MRCK in mediating HeLa cell elongation induced by the C1 domain ligand HMI-1a3.
2014
2014
C1 domain-targeted isophthalates as protein kinase C modulators: structure-based design, structure-activity relationships and biological activities.
Protein kinase C (PKC) is a serine/threonine kinase belonging to the AGC family. PKC isoenzymes are activated by phospholipid… 
2013
2013
The DAG-responsive C1 domain as a drug target: structure-activity and in vitro pharmacology of isophthalate derivatives
Diacylglycerol (DAG) is a ubiquitous lipid second messenger that transmits signals from cell membrane receptors to intracellular… 
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