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HM-30181

Known as: HM30181 
National Institutes of Health

Papers overview

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2019
2019
Affinity-based Protein Profiling Reveals Cellular Targets of Photoreactive Anticancer Inhibitors.
Affinity-based protein profiling has proven to be a powerful method in target identification of bioactive molecules. Here this… 
2016
2016
Effect of HM30181 mesylate salt-loaded microcapsules on the oral absorption of paclitaxel as a novel P-glycoprotein inhibitor.
Highly Cited
2015
Highly Cited
2015
HM30181 Derivatives as Novel Potent and Selective Inhibitors of the Breast Cancer Resistance Protein (BCRP/ABCG2).
The breast cancer resistance protein (BCRP, ABCG2) belongs to the superfamily of ATP binding-cassette (ABC) proteins. In addition… 
2014
2014
Effects of HM30181, a P-glycoprotein inhibitor, on the pharmacokinetics and pharmacodynamics of loperamide in healthy volunteers.
AIMS HM30181 is a third generation P-glycoprotein (P-gp) inhibitor currently under development. The objectives of this study were… 
2013
2013
Sustained Increase in the Oral Bioavailability of Loperamide after a Single Oral Dose of HM30181, a P‐glycoprotein Inhibitor, in Healthy Male Participants
HM30181 is a new P‐glycoprotein (P‐gp) inhibitor. This study was conducted to investigate the effect of HM30181 and its duration… 
2012
2012
Interaction of HM30181 with P-glycoprotein at the murine blood-brain barrier assessed with positron emission tomography.
Highly Cited
2010
Highly Cited
2010
Selective inhibition of MDR1 (ABCB1) by HM30181 increases oral bioavailability and therapeutic efficacy of paclitaxel.
2007
2007
Characterization of Human Liver Cytochrome P-450 Enzymes Involved in the O-demethylation of a New P-glycoprotein Inhibitor HM-30181
HM-30181, 4-oxo-4H-chromene-2-carboxylic acid [2-(2-{4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenyl}-2H… 
2006
2006
Simultaneous determination of paclitaxel and a new P-glycoprotein inhibitor HM-30181 in rat plasma by liquid chromatography with tandem mass spectrometry.
An LC-MS/MS method for the simultaneous determination of a new P-glycoprotein inhibitor 4-oxo-4H-chromene-2-carboxylic acid [2-(2… 
2006
2006
Metabolism of a new P-glycoprotein inhibitor HM-30181 in rats using liquid chromatography/electrospray mass spectrometry.
HM-30181, 4-oxo-4H-chromene-2-carboxylic acid, [2-(2-{4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenyl}-2H… 
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