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HL-60/MX2

HL-60/MX2 is a mitoxantrone resistant derivative of the HL-60 cell line. HL-60/MX2 is approximately 35 fold less sensitive to mitoxantrone than the… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Synthesis and Mechanism Studies of 1,3-Benzoazolyl Substituted Pyrrolo[2,3-b]pyrazine Derivatives as Nonintercalative Topoisomerase II Catalytic Inhibitors.
Novel topoisomerase II (Topo II) inhibitors have gained considerable interest for the development of anticancer agents. In this… 
2010
2010
N,N-Dimethyl phytosphingosine sensitizes HL-60/MX2, a multidrug-resistant variant of HL-60 cells, to doxorubicin-induced cytotoxicity through ROS-mediated release of cytochrome c and AIF
Doxorubicin (Dox) is widely used to treat a variety of tumors. However, resistance to this drug is common, making successful… 
Highly Cited
2007
Highly Cited
2007
Induction of apoptosis by plumbagin through reactive oxygen species-mediated inhibition of topoisomerase II.
Highly Cited
2007
Highly Cited
2007
Antitumor properties of diastereomeric and geometric analogs of vitamin D3
Analogs of 1,25-dihydroxyvitamin D3 with a reversed configuration at C-1 or C-24 and E or Z geometry of the double bond at C-22… 
2007
2007
Biological properties of new derivatives of daunorubicin.
In the search for new derivatives of daunorubicin with high activity and/or the ability to overcome the drug resistance barrier… 
2006
2006
Enhanced cellular respiration in cells exposed to doxorubicin.
Doxorubicin executes topoisomerase II mediated apoptosis, a process known to result in mitochondrial dysfunction, such as the… 
2003
2003
Cytotoxicity and cell cycle effects of novel indolo[2,3-b]quinoline derivatives.
Cellular effects of novel indolo[2,3-b]quinoline derivatives were studied. These compounds are synthetic analogs of plant… 
2001
2001
DNA topoisomerase II inhibition by peroxisomicine A(1) and its radical metabolite induces apoptotic cell death of HL-60 and HL-60/MX2 human leukemia cells.
Peroxisomicine A(1) (T-514) is a dimeric anthracenone first isolated from the plant Karwinskia humboldtiana. The compound… 
2000
2000
A novel use for the comet assay: detection of topoisomerase II inhibitors.
BACKGROUND The simple and quick comet assay can quantitatively detect DNA cleavage in cells. This study aimed to determine… 
1992
1992
Decreased P-glycoprotein expression in multidrug-sensitive and -resistant human myeloma cells induced by the cytokine leukoregulin.
Modulation of the expression of P-glycoprotein, a plasma membrane protein associated with multidrug resistance, was examined in… 
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