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HL-60/MX2
HL-60/MX2 is a mitoxantrone resistant derivative of the HL-60 cell line. HL-60/MX2 is approximately 35 fold less sensitive to mitoxantrone than the…
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National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Synthesis and Mechanism Studies of 1,3-Benzoazolyl Substituted Pyrrolo[2,3-b]pyrazine Derivatives as Nonintercalative Topoisomerase II Catalytic Inhibitors.
Peng Li
,
Ping-yao Zeng
,
+8 authors
Zhishu Huang
Journal of Medicinal Chemistry
2016
Corpus ID: 35739221
Novel topoisomerase II (Topo II) inhibitors have gained considerable interest for the development of anticancer agents. In this…
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2010
2010
N,N-Dimethyl phytosphingosine sensitizes HL-60/MX2, a multidrug-resistant variant of HL-60 cells, to doxorubicin-induced cytotoxicity through ROS-mediated release of cytochrome c and AIF
B. Kim
,
Yun-Jung Choi
,
Yong Heon Lee
,
Y. Joe
,
S. Hong
Apoptosis
2010
Corpus ID: 25683248
Doxorubicin (Dox) is widely used to treat a variety of tumors. However, resistance to this drug is common, making successful…
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Highly Cited
2007
Highly Cited
2007
Induction of apoptosis by plumbagin through reactive oxygen species-mediated inhibition of topoisomerase II.
A. Kawiak
,
J. Piosik
,
+5 authors
E. Lojkowska
Toxicology and Applied Pharmacology
2007
Corpus ID: 29027384
Highly Cited
2007
Highly Cited
2007
Antitumor properties of diastereomeric and geometric analogs of vitamin D3
J. Wietrzyk
,
M. Chodyński
,
H. Fitak
,
E. Wojdat
,
A. Kutner
,
A. Opolski
Anti-Cancer Drugs
2007
Corpus ID: 13359822
Analogs of 1,25-dihydroxyvitamin D3 with a reversed configuration at C-1 or C-24 and E or Z geometry of the double bond at C-22…
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2007
2007
Biological properties of new derivatives of daunorubicin.
Malgorzata Wasowska-Lukawska
,
J. Wietrzyk
,
A. Opolski
,
J. Oszczapowicz
,
I. Oszczapowicz
In Vivo
2007
Corpus ID: 42119287
In the search for new derivatives of daunorubicin with high activity and/or the ability to overcome the drug resistance barrier…
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2006
2006
Enhanced cellular respiration in cells exposed to doxorubicin.
A. Souid
,
H. Penefsky
,
P. D. Sadowitz
,
B. Toms
Molecular Pharmaceutics
2006
Corpus ID: 23744391
Doxorubicin executes topoisomerase II mediated apoptosis, a process known to result in mitochondrial dysfunction, such as the…
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2003
2003
Cytotoxicity and cell cycle effects of novel indolo[2,3-b]quinoline derivatives.
R. Humeniuk
,
L. Kaczmarek
,
W. Peczyńska‐Czoch
,
E. Marcinkowska
Oncology Research
2003
Corpus ID: 23430125
Cellular effects of novel indolo[2,3-b]quinoline derivatives were studied. These compounds are synthetic analogs of plant…
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2001
2001
DNA topoisomerase II inhibition by peroxisomicine A(1) and its radical metabolite induces apoptotic cell death of HL-60 and HL-60/MX2 human leukemia cells.
A. Lansiaux
,
W. Laine
,
+6 authors
C. Bailly
Chemical Research in Toxicology
2001
Corpus ID: 20539195
Peroxisomicine A(1) (T-514) is a dimeric anthracenone first isolated from the plant Karwinskia humboldtiana. The compound…
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2000
2000
A novel use for the comet assay: detection of topoisomerase II inhibitors.
G. Salti
,
T. K. Das Gupta
,
A. Constantinou
Anticancer Research
2000
Corpus ID: 36465079
BACKGROUND The simple and quick comet assay can quantitatively detect DNA cleavage in cells. This study aimed to determine…
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1992
1992
Decreased P-glycoprotein expression in multidrug-sensitive and -resistant human myeloma cells induced by the cytokine leukoregulin.
C. Evans
,
P. D. Baker
Cancer Research
1992
Corpus ID: 15421560
Modulation of the expression of P-glycoprotein, a plasma membrane protein associated with multidrug resistance, was examined in…
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