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HIV Reverse Transcriptase

Known as: Transcriptase, HIV Reverse, Reverse Transcriptase, HIV, HIV Reverse Transcriptase [Chemical/Ingredient] 
A reverse transcriptase encoded by the POL GENE of HIV. It is a heterodimer of 66 kDa and 51 kDa subunits that are derived from a common precursor… 
National Institutes of Health

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In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects

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reverse transcriptase, Human immunodeficiency virus 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Role of induced fit in limiting discrimination against AZT by HIV reverse transcriptase.
Single turnover kinetic studies were conducted using fluorescently labeled HIV reverse transcriptase (RT) to evaluate the role of… 
2007
2007
Virological response to Salvage Therapy in HIV-Infected Persons Carrying the Reverse Transcriptase K65R Mutation
Background The effect of the HIV reverse transcriptase K65R mutation on virological response to salvage therapy has not been… 
2006
2006
Virologic and Enzymatic Studies Revealing the Mechanism of K65R- and Q151M-Associated HIV-1 Drug Resistance Towards Emtricitabine and Lamivudine
Emtricitabine (FTC) and lamivudine (3TC) are deoxycytidine analogues with potent and selective inhibition of human… 
Review
2004
Review
2004
Biochemical and mechanistic basis for the activity of nucleoside analogue inhibitors of HIV reverse transcriptase.
HIV encodes an RNA directed DNA polymerase (reverse transcriptase, RT) that is an essential enzyme in the viral replication cycle… 
2004
2004
QSAR study on some anti-HIV HEPT analogues using physicochemical and topological parameters.
1997
1997
Structure of a DNA analog of the primer for HIV-1 RT second strand synthesis.
The non-self-complementary DNA decamer C-A-A-A-G-A-A-A-A-G/C-T-T-T-T-C-T-T-T-G is a DNA/DNA analogue of a portion of the… 
Highly Cited
1996
Highly Cited
1996
Novel mutation (K70E) in human immunodeficiency virus type 1 reverse transcriptase confers decreased susceptibility to 9-[2-(phosphonomethoxy)ethyl]adenine in vitro
9-[2-(phosphonomethoxy)ethyl]adenine (PMEA), an acyclic nucleoside phosphonate analog, is active against several retroviruses and… 
Highly Cited
1989
Highly Cited
1989
Fidelity of human immunodeficiency virus type I reverse transcriptase in copying natural DNA.
Reverse transcriptase from the human immunodeficiency virus type I (HIV-1) was expressed in E. coli and purified to near… 
1988
1988
Kinetics and inhibition of reverse transcriptase from human and simian immunodeficiency viruses
Reverse transcriptase from the simian immunodeficiency virus (SIV) was found to have kinetic behavior similar to that of enzyme… 
Highly Cited
1987
Highly Cited
1987
Characterization and clinical association of antibody inhibitory to HIV reverse transcriptase activity.
Reverse transcriptase activity of the human immunodeficiency virus (HIV) was blocked in vitro by immunoglobulin G (IgG) derived… 
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