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HIRA gene

Known as: TUP1, DIGEORGE SYNDROME CRITICAL REGION GENE 1, histone cell cycle regulator 
This gene plays a role in heterochromatin formation.
National Institutes of Health

Related topics

Related topics

6 relations
Chromatin Structural ProcessHIRA protein, humanHIRIP3 geneMitotic Cell Cycle

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HIRA wt Allele

Papers overview

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Highly Cited
2015
Highly Cited
2015
Critical Role of Histone Turnover in Neuronal Transcription and Plasticity
Highly Cited
2007
Highly Cited
2007
CHD1 Motor Protein Is Required for Deposition of Histone Variant H3.3 into Chromatin in Vivo
The organization of chromatin affects all aspects of nuclear DNA metabolism in eukaryotes. H3.3 is an evolutionarily conserved… 
Highly Cited
2005
Highly Cited
2005
The histone H3.3 chaperone HIRA is essential for chromatin assembly in the male pronucleus
In sexually reproducing animals, a crucial step in zygote formation is the decondensation of the fertilizing sperm nucleus into a… 
Highly Cited
2005
Highly Cited
2005
Systematic assessment of atypical deletions reveals genotype–phenotype correlation in 22q11.2
Introduction: Clinical variability associated with the common 22q11.2 microdeletion is well known, and has led to a broad… 
Highly Cited
2005
Highly Cited
2005
Maize rough sheath2 and Its Arabidopsis Orthologue ASYMMETRIC LEAVES1 Interact with HIRA, a Predicted Histone Chaperone, to Maintain knox Gene Silencing and Determinacy during Organogenesisw⃞
Plant shoots are characterized by indeterminate growth resulting from the action of a population of stem cells in the shoot… 
Highly Cited
2002
Highly Cited
2002
HIRA is critical for a nucleosome assembly pathway independent of DNA synthesis.
Highly Cited
2001
Highly Cited
2001
Regulatory mechanisms controlling expression of the DAN/TIR mannoprotein genes during anaerobic remodeling of the cell wall in Saccharomyces cerevisiae.
The DAN/TIR genes of Saccharomyces cerevisiae encode homologous mannoproteins, some of which are essential for anaerobic growth… 
Highly Cited
1994
Highly Cited
1994
The global transcriptional regulators, SSN6 and TUP1, play distinct roles in the establishment of a repressive chromatin structure.
Repression of a-cell specific gene expression in yeast alpha cells requires MAT alpha 2 and MCM1, as well as two global… 
Highly Cited
1994
Highly Cited
1994
The WD repeats of Tup1 interact with the homeo domain protein alpha 2.
Tup1 and Ssn6 transcriptionally repress a wide variety of genes in yeast but do not appear to bind DNA. We provide genetic and… 
Review
1993
Review
1993
DNA damage and cell cycle regulation of ribonucleotide reductase
Ribonucleotide reductase (RNR) catalyzes the rate limiting step in the production of deoxyribonucleotides needed for DNA… 
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