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HHV8 ORF50 Gene

Known as: HHV-8 RTA, HHV8 ORF50, Kaposi Sarcoma Herpes Virus ORF50 Gene 
HHV8 ORF50, which encodes putative transcription activator ORF50 protein, is involved in the conversion from the latent phase to the lytic phase of… 
National Institutes of Health

Related topics

Related topics

5 relations
Lytic PhaseRta protein, Human herpesvirus 8Transcriptional ActivationVirus Physiological Phenomena

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Construction of a Lytically Replicating Kaposi's Sarcoma-Associated Herpesvirus
ABSTRACT Karposi's sarcoma-associated herpesvirus (KSHV) is found predominantly in a latent state in most cell types, impeding… 
2010
2010
Convergence of Kaposi's Sarcoma-Associated Herpesvirus Reactivation with Epstein-Barr Virus Latency and Cellular Growth Mediated by the Notch Signaling Pathway in Coinfected Cells
ABSTRACT Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent of primary effusion lymphoma (PEL). All PEL cell… 
2004
2004
Autoregulation of DNA Binding and Protein Stability of Kaposi's Sarcoma-Associated Herpesvirus ORF50 Protein
ABSTRACT A transcriptional activator encoded in open reading frame 50 (ORF50) of Kaposi's sarcoma-associated herpesvirus (KSHV… 
2004
2004
Protection against wild-type murine gammaherpesvirus-68 latency by a latency-deficient mutant.
A murine gammaherpesvirus-68 (MHV-68) mutant with deregulated transcription of its ORF50 transactivator was severely impaired in… 
Highly Cited
2002
Highly Cited
2002
Binding of ricin A-chain to negatively charged phospholipid vesicles leads to protein structural changes and destabilizes the lipid bilayer.
Ricin is a heterodimeric protein toxin in which a catalytic polypeptide (the A-chain or RTA) is linked by a disulfide bond to a… 
2002
2002
Kaposi's sarcoma-associated herpesvirus open reading frame (ORF) 50 transactivates K8 and ORF57 promoters via heterogeneous response elements.
Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) belongs to the human gammaherpesvirus family that undergoes both lytic and… 
Highly Cited
2001
Highly Cited
2001
Kaposi's Sarcoma-Associated Herpesvirus Open Reading Frame 50 Represses p53-Induced Transcriptional Activity and Apoptosis
ABSTRACT Kaposi's sarcoma-associated herpesvirus (KSHV) open reading frame 50 (ORF50) encodes a viral transcriptional activator… 
Highly Cited
1998
Highly Cited
1998
Activation of human herpesvirus 8 (HHV-8) thymidine kinase (TK) TATAA-less promoter by HHV-8 ORF50 gene product is SP1 dependent.
Human herpesvirus 8 (HHV-8) is a newly discovered virus closely associated with Kaposi's sarcoma and primary effusion lymphomas… 
Highly Cited
1997
Highly Cited
1997
The herpesvirus saimiri ORF50 gene, encoding a transcriptional activator homologous to the Epstein-Barr virus R protein, is transcribed from two distinct promoters of different temporal phases
The mRNA species encoding the herpesvirus saimiri (HVS) homolog of the Epstein-Barr virus R transcriptional activator (termed… 
Highly Cited
1980
Highly Cited
1980
Epidermal growth factor-toxin A chain conjugates: EGF-Ricin A is a potent toxin while EGF-diphtheria fragment A is nontoxic
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