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HEY2 gene

Known as: GRL, CHF1, FORMERLY, CARDIOVASCULAR BASIC-LOOP-HELIX FACTOR, FORMERLY 
This gene is involved in both transcriptional regulation and Notch signaling pathways.
National Institutes of Health

Related topics

Related topics

7 relations
HEY2 wt AlleleHairy/Enhancer-Of-Split Related With YRPW Motif Protein 2Pattern FormationSignal Transduction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Downregulation of transforming growth factor, beta receptor 2 and Notch signaling pathway in human abdominal aortic aneurysm.
Highly Cited
2007
Highly Cited
2007
Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate.
Highly Cited
2007
Highly Cited
2007
Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal…
Notch signaling pathway maintains stem cells through transcriptional activation of HES/HEY family members to repress tissue… 
Highly Cited
2005
Highly Cited
2005
Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system.
Highly Cited
2005
Highly Cited
2005
HERP1 Inhibits Myocardin-Induced Vascular Smooth Muscle Cell Differentiation by Interfering With SRF Binding to CArG Box
Objective—Myocardin is a coactivator of serum response factor (SRF) required for vascular smooth muscle cell (VSMC… 
Highly Cited
2003
Highly Cited
2003
Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression.
Highly Cited
2002
Highly Cited
2002
Mouse gridlock No Aortic Coarctation or Deficiency, but Fatal Cardiac Defects in Hey2 −/− Mice
Highly Cited
2002
Highly Cited
2002
Coordinate Notch3-Hairy-related Transcription Factor Pathway Regulation in Response to Arterial Injury
The Notch family of receptors and downstream effectors plays a critical role in cell fate determination during vascular ontogeny… 
Highly Cited
2002
Highly Cited
2002
HERP1 Is a Cell Type-specific Primary Target of Notch*
Notch signaling is involved in many cell fate determination events in metazoans. Ligand binding results in proteolytic cleavage… 
Highly Cited
1999
Highly Cited
1999
HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments.
Members of the Hairy/Enhancer of Split family of basic helix-loop-helix (bHLH) transcription factors are regulated by the Notch… 
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