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HDAC Inhibitor ACY-241
Known as:
ACY-241
, Histone Deacetylase Inhibitor ACY-241
An orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon oral administration, ACY-241 inhibits the…
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National Institutes of Health
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NCIt Antineoplastic Agent Terminology
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2016
2016
Abstract 4822: Combination efficacy of the selective HDAC inhibitor ACY-241 and paclitaxel in solid tumor models
Pengyu Huang
,
Ingrid Almeciga-Pinto
,
Min Yang
,
Simon S. Jones
,
S. Quayle
2016
Corpus ID: 78669476
ACY 241 is a new, orally available and selective histone deacetylase (HDAC) 6 inhibitor in clinical development in combination…
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2016
2016
Abstract 3958: Tubulin hyper-acetylation in blood lymphocytes: pharmacodynamic (PD) biomarker for the selective histone deacetylase (HDAC) 6 inhibitors ricolinostat and ACY-241 in multiple myeloma…
D. Tamang
,
J. Supko
,
K. Bhol
,
C. Wheeler
,
Simon S. Jones
,
Min Yang
2016
Corpus ID: 78374316
2015
2015
Abstract 5380: Selective HDAC inhibition by ricolinostat (ACY-1215) or ACY-241 synergizes with IMiD® immunomodulatory drugs in Multiple Myeloma (MM) and Mantle Cell Lymphoma (MCL) cells
S. Quayle
,
Ingrid Almeciga-Pinto
,
D. Tamang
,
Min Yang
,
Simon S. Jones
2015
Corpus ID: 76483435
Histone deacetylase (HDAC) enzymes are attractive therapeutic targets in oncology, but non-selective HDAC inhibitors have led to…
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