Learn More
The generation of functional hepatocytes independent of donor liver organs is of great therapeutic interest with regard to regenerative medicine and possible cures for liver disease. Induced hepatic differentiation has been achieved previously using embryonic stem cells or induced pluripotent stem cells. Particularly, hepatocytes generated from a patient's(More)
Mitogen-activated protein (MAP) kinases comprise a family of protein-serine/threonine kinases, which are highly conserved in protein structures from unicellular eukaryotic organisms to multicellular organisms, including mammals. These kinases, including ERKs, JNKs and p38s, are regulated by a phosphorelay cascade, with a prototype of three protein kinases(More)
The generation of large numbers of functional human hepatocytes for cell-based approaches to liver disease is an important and unmet goal. Direct reprogramming of fibroblasts to hepatic lineages could offer a solution to this problem but so far has only been achieved with mouse cells. Here, we generated human induced hepatocytes (hiHeps) from fibroblasts by(More)
Echogenic bubble formulations have wide applications in both disease diagnosis and therapy. In the current study, nanobubbles were prepared and the contrast agent function was evaluated in order to study the nanosized bubble's property for ultrasonic imaging. Coumarin-6 as a model drug was loaded into nanobubbles to investigate the drug delivery potential(More)
Acute liver failure (ALF) is a life-threatening illness. The extracorporeal cell-based bioartificial liver (BAL) system could bridge liver transplantation and facilitate liver regeneration for ALF patients by providing metabolic detoxification and synthetic functions. Previous BAL systems, based on hepatoma cells and non-human hepatocytes, achieved limited(More)
Active target localization is one of the study emphases in wireless sensor network (WSN). When time difference of arrival (TDOA) and frequency difference of arrival (FDOA) measurements are used to target localization, the measurements are nonlinearly related to the target location parameters. By the analysis of TDOA and FDOA linearized equations, when there(More)
Target localization is one of the basic functions of wireless sensor networks. In the target localization algorithms, the problem of how many sensors are needed and how they are deployed is what we are concerned about in this paper. The authors of (K.C. Ho et al., 2007) present the mathematical expression of Cramer-Rao lower bound for the localization(More)
Hepatocytes are functionally heterogeneous and are divided into two distinct populations based on their metabolic zonation: the periportal and pericentral hepatocytes. During liver injury and regeneration, the cellular dynamics of these two distinct populations remain largely elusive. Here we show that major facilitator super family domain containing 2a(More)
Spectrum sensing is an important functionality of Cognitive Radio (CR). In this paper, an optimal multi-channel spectrum sensing strategy for energy-constrained cognitive radio networks (CRNs) is proposed. Under constraints of energy consumption and interference to the primary communication network, the multi-channel spectrum sensing problem is formulated(More)