Pengyu Huang

Kun Ping Lu3
Yandan Yao3
Chun-Hau Chen3
3Kun Ping Lu
3Yandan Yao
3Chun-Hau Chen
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  • Asami Kondo, Koorosh Shahpasand, Rebekah Mannix, Jianhua Qiu, Juliet Moncaster, Chun-Hau Chen +16 others
  • 2015
Traumatic brain injury (TBI), characterized by acute neurological dysfunction, is one of the best known environmental risk factors for chronic traumatic encephalopathy and Alzheimer's disease, the defining pathologic features of which include tauopathy made of phosphorylated tau protein (P-tau). However, tauopathy has not been detected in the early stages(More)
Proline-directed phosphorylation is regulated by the prolyl isomerase Pin1, which plays a fundamental role in driving breast cancer stem-like cells (BCSCs). Rab2A is a small GTPase critical for vesicle trafficking. Here, we show that Pin1 increases Rab2A transcription to promote BCSC expansion and tumorigenesis in vitro and in vivo. Mechanistically, Rab2A(More)
Acute liver failure (ALF) is a life-threatening illness. The extracorporeal cell-based bioartificial liver (BAL) system could bridge liver transplantation and facilitate liver regeneration for ALF patients by providing metabolic detoxification and synthetic functions. Previous BAL systems, based on hepatoma cells and non-human hepatocytes, achieved limited(More)
Using spheropolygon-based simulations and contact slope analysis, we investigate the effects of surface topography and atomic scale friction on the macroscopically observed friction between rigid blocks with fractal surface structures. From our mathematical derivation, the angle of macroscopic friction is the result of the sum of the angle of atomic(More)
  • Asami Kondo, Koorosh Shahpasand, Rebekah Mannix, Jianhua Qiu, Juliet Moncaster, Chun-Hau Chen +16 others
  • 2015
interests were reviewed and are managed by BIDMC in accordance with its conflict of interest policy. Readers are welcome to comments on the online version of the paper. Online Content Methods, along with any Extended Data display items and source Data, are available in the online version of the paper; references unique to the sections appear only in the(More)
Recent advances in unmanned aerial vehicle (UAV) and wireless charging technologies have made it practical to introduce a mobile node into Wireless Sensor Networks (WSN). This mobile node with sink ability or charging equipment on it can travel around the entire network to gather data from isolate sensor nodes or charge the nodes wirelessly. This can help(More)