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HAS2 gene

Known as: HA Synthase 2, Hyaluronan Synthase 2, Hyaluronic Acid Synthase 2 
Hyaluronan synthase 2 (552 aa, ~64 kDa) is encoded by the human HAS2 gene. This protein plays a role in the biosynthesis of hyaluronic acid.
National Institutes of Health

Related topics

Related topics

7 relations
Carbohydrate MetabolismEnzyme GeneGlycosyltransferase GeneIntegral Membrane Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Expression of maturation genes and their receptors during in vitro maturation of sheep COCs in the presence and absence of somatic cells of cumulus origin.
2012
2012
Melanoma cells control HA synthesis in peritumoral fibroblasts via PDGF-AA and PDGF-CC: impact on melanoma cell proliferation.
The microenvironment surrounding tumors has an important role in tumor progression. Fibroblasts (Fbs) of the tumor stroma receive… 
2008
2008
Up-regulation of hyaluronan synthase genes in cultured human epidermal keratinocytes by UVB irradiation.
2008
2008
The malignant phenotype of breast cancer cells is reduced by COX-2 silencing.
The cyclooxygenase (COX) pathway is currently targeted for therapeutic intervention in different cancers. We have previously… 
2007
2007
A Rapid Transient Increase in Hyaluronan Synthase-2 mRNA Initiates Secretion of Hyaluronan by Corneal Keratocytes in Response to Transforming Growth Factor β*
Keratocytes of the corneal stroma produce transparent extracellular matrix devoid of hyaluronan (HA); however, in corneal… 
2005
2005
Regulation of hyaluronan synthase-2 expression in human intestinal mesenchymal cells: mechanisms of interleukin-1beta-mediated induction.
Elevated levels of hyaluronan are associated with numerous inflammatory diseases including inflammatory bowel disease. The… 
Highly Cited
2004
Highly Cited
2004
c-Jun N-terminal kinase and, to a lesser extent, p38 mitogen-activated protein kinase regulate inducible nitric oxide synthase expression in hyaluronan fragments-stimulated BV-2 microglia
2001
2001
Molecular cloning of rabbit hyaluronic acid synthases and their expression patterns in synovial membrane and articular cartilage.
Highly Cited
1999
Highly Cited
1999
The effect of mechanical strain on hyaluronan metabolism in embryonic fibrocartilage cells.
1999
1999
Hyaluronan synthase expression in bovine eyes.
PURPOSE Hyaluronan (HA), a high-molecular-weight linear glycosaminoglycan, is a component of the extracellular matrix (ECM). It… 
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