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Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.
It is demonstrated that homozygous deletion of the p53 tumor suppressor gene via homologous recombination in a human cancer cell line promotes the neovascularization and growth of tumor xenografts in nude mice.
HIF-dependent antitumorigenic effect of antioxidants in vivo.
MRI of the tumor microenvironment
- R. Gillies, N. Raghunand, G. Karczmar, Z. Bhujwalla
- BiologyJournal of magnetic resonance imaging : JMRI
- 1 October 2002
This review attempts to identify techniques and their application to tumor biology, with an emphasis on nuclear magnetic resonance (NMR) approaches, using electron MR, optical, and radionuclear imaging techniques.
Choline metabolism in malignant transformation
Abnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression, and increased levels of these compounds provide a non-invasive biomarker of transformation, staging and response to therapy.
Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells.
It is demonstrated that progression of human mammary epithelial cells from normal to malignant phenotype is associated with altered membrane choline phospholipid metabolism, and a "glycerophosphocholine to phosphocholine switch" was apparent with immortalization.
Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer.
Stable overexpression of Twist in a breast cancer cell line, MCF-7, altered its morphology to a fibroblastic-like phenotype, which exhibited protein markers representative of a mesenchymal transformation that is pivotal for the transformation into an aggressive breast cancer phenotype.
Enhancement of chemotherapy by manipulation of tumour pH
It is demonstrated that MCF-7 human breast cancer cells in vitro are more susceptible to doxorubicin toxicity at pH 7.4, compared to pH 6.8, the first in vivo demonstration of this important phenomenon.
MR molecular imaging of the Her‐2/neu receptor in breast cancer cells using targeted iron oxide nanoparticles
- D. Artemov, N. Mori, B. Okollie, Z. Bhujwalla
- Biology, ChemistryMagnetic resonance in medicine
- 1 March 2003
In this study Her‐2/neu receptors were imaged in a panel of breast cancer cells expressing different numbers of the receptors on the cell membrane, and iron oxide nanoparticles were attached to the cell surface and were not internalized into the cells, which is a major advantage for in vivo applications of the method.
31P-MRS measurements of extracellular pH of tumors using 3-aminopropylphosphonate.
The extracellular pH (pHex) of tumors is generally acidic. However, it is only recently that noninvasive magnetic resonance spectroscopic (MRS) measurements have determined that the intracellular pH…
Overexpression of vascular endothelial growth factor 165 drives peritumor interstitial convection and induces lymphatic drain: magnetic resonance imaging, confocal microscopy, and histological…
- H. Dafni, T. Israely, Z. Bhujwalla, L. Benjamin, M. Neeman
- Biology, MedicineCancer research
- 15 November 2002
Results revealed a direct link between expression of VEGF165 and peritumor lymphatic drain, thus suggesting a possible role for tumor-derived V EGF in metastatic spread to sentinel lymph nodes.