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Growth Hormone Receptor

Known as: Growth Hormone Receptors, Receptors, Somatotropin [Chemical/Ingredient], Somatotropin Receptors 
Cell surface proteins that bind GROWTH HORMONE with high affinity and trigger intracellular changes influencing the behavior of cells. Activation of… 
National Institutes of Health

Related topics

Related topics

11 relations
GHR geneGrowth HormoneHuman Placental LactogenIn Blood

Narrower (2)

GHR protein, humanGHR1 protein, zebrafish

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects
The growth hormone receptor (GHR), although most well known for regulating growth, has many other important biological functions… 
Highly Cited
2009
Highly Cited
2009
Liver-specific Deletion of the Growth Hormone Receptor Reveals Essential Role of Growth Hormone Signaling in Hepatic Lipid Metabolism*♦
Growth hormone (GH) plays a pivotal role in growth and metabolism, with growth promotion mostly attributed to generation of… 
Highly Cited
2008
Highly Cited
2008
Exogenous ghrelin modulates release of pro-inflammatory and anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways.
Highly Cited
2006
Highly Cited
2006
The co-existence of two growth hormone receptors in teleost fish and their differential signal transduction, tissue distribution and hormonal regulation of expression in seabream.
Two genomic contigs of putative growth hormone receptors (GHRs) were identified in fugu and zebrafish genomes by in silico… 
Highly Cited
2005
Highly Cited
2005
Model for growth hormone receptor activation based on subunit rotation within a receptor dimer
Growth hormone is believed to activate the growth hormone receptor (GHR) by dimerizing two identical receptor subunits, leading… 
Highly Cited
2005
Highly Cited
2005
Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction.
Reduced IGF-I/insulin signaling and caloric restriction (CR) are known to extend the life span and delay age-related diseases. To… 
Highly Cited
2000
Highly Cited
2000
Bone homeostasis in growth hormone receptor-null mice is restored by IGF-I but independent of Stat5.
Growth hormone (GH) regulates both bone growth and remodeling, but it is unclear whether these actions are mediated directly by… 
Highly Cited
2000
Highly Cited
2000
Endocytosis and Degradation of the Growth Hormone Receptor Are Proteasome-dependent*
The ubiquitin conjugation system is involved in ligand-induced endocytosis of the growth hormone receptor (GHR) via a cytosolic… 
Highly Cited
1993
Highly Cited
1993
Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase
Highly Cited
1976
Highly Cited
1976
Regulation of receptor concentration by homologous hormone. Effect of human growth hormone on its receptor in IM-9 lymphocytes.
When cultured human lymphocytes of the IM-9 line were exposed to human growth hormone (hGH) at 37 degrees, washed for 2 hours… 
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