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Growth Hormone-Producing Pituitary Gland Neoplasm

Known as: Somatotrophinoma, Growth Hormone Secreting Tumor of Pituitary Gland, Growth Hormone Secreting Neoplasm of the Pituitary 
An adenoma or carcinoma of the anterior lobe of the pituitary gland that produces growth hormone.
National Institutes of Health

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20 relations
Adenohypophysial CellBase of skull structureBone structure of craniumBrain

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Pituitary growth hormone cell adenoma

Papers overview

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Highly Cited
2013
Highly Cited
2013
Genetic analysis in young patients with sporadic pituitary macroadenomas: besides AIP don't forget MEN1 genetic analysis.
CONTEXT Germline mutations in the aryl hydrocarbon receptor interacting protein gene (AIP) have been identified in young patients… 
Highly Cited
2012
Highly Cited
2012
Succinate dehydrogenase (SDH) D subunit (SDHD) inactivation in a growth-hormone-producing pituitary tumor: a new association for SDH?
BACKGROUND Mutations in the subunits B, C, and D of succinate dehydrogenase (SDH) mitochondrial complex II have been associated… 
Highly Cited
2011
Highly Cited
2011
High prevalence of AIP gene mutations following focused screening in young patients with sporadic pituitary macroadenomas.
BACKGROUND Aryl hydrocarbon receptor interacting protein (AIP) mutations (AIPmut) cause aggressive pituitary adenomas in young… 
Review
2007
Review
2007
The clinical, pathological, and genetic features of familial isolated pituitary adenomas.
Pituitary adenomas occur in a familial setting in multiple endocrine neoplasia type 1 (MEN1) and Carney's complex (CNC), which… 
Highly Cited
2006
Highly Cited
2006
Clinical characterization of familial isolated pituitary adenomas.
CONTEXT Familial pituitary adenomas occur rarely in the absence of multiple endocrine neoplasia type 1 (MEN1) and Carney complex… 
Highly Cited
2006
Highly Cited
2006
FOXA1: Growth inhibitor and a favorable prognostic factor in human breast cancer
The transcription factor Forkhead‐box A1 (Foxa1), a member of the FOX class of transcription factors, has been implicated in the… 
Highly Cited
1999
Highly Cited
1999
Hypermethylation of the p16/CDKN2A/MTS1 gene and loss of protein expression is associated with nonfunctional pituitary adenomas but not somatotrophinomas
The cyclin‐dependent kinase inhibitor 2A/multiple tumor suppressor gene 1 (CDKN2A/MTS1/p16) plays an important role in the… 
Highly Cited
1996
Highly Cited
1996
Spectrum of pituitary disease in multiple endocrine neoplasia type 1 (MEN 1): clinical, biochemical, and radiological features of pituitary disease in a large MEN 1 kindred.
Prolactinomas and somatotropinomas are reported to be the pituitary lesions most frequently associated with multiple endocrine… 
Highly Cited
1993
Highly Cited
1993
Two mutations in the hormone binding domain of the vitamin D receptor cause tissue resistance to 1,25 dihydroxyvitamin D3.
We have identified and characterized two mutations in the hormone binding domain of the vitamin D receptor (VDR) in patients with… 
Highly Cited
1985
Highly Cited
1985
Regulation of growth hormone release from cultured human pituitary adenomas by somatomedins and insulin.
GH secretion is stimulated by hypothalamic GH-releasing factor (GHRH) and inhibited by somatostatin. Since GH induces the… 
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