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Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline.
TLDR
This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe both the strength of recommendations and the quality of evidence for diagnosis and treatment of hyperprolactinemia. Expand
CTCF Mediates Interchromosomal Colocalization Between Igf2/H19 and Wsb1/Nf1
TLDR
These findings demonstrate that CTCF mediates an interchromosomal association, perhaps by directing distant DNA segments to a common transcription factory, and the data provide a model for long-range allele-specific associations between gene regions on different chromosomes that suggest a framework for DNA recombination and RNA trans-splicing. Expand
Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts.
TLDR
The tissue-specific and gestational-age dependent expression of hTERT mRNA seen in human development suggests the presence of at least two regulatory mechanisms controlling the activity of telomerase: transcriptional control of the h TERT gene and alternate splicing of hterT transcripts. Expand
Systematic Review: The Effects of Growth Hormone on Athletic Performance
TLDR
A systematic review of randomized, controlled trials was performed to determine the effects of growth hormone therapy on athletic performance in healthy, physically fit, young adults and synthesize the evidence on adverse events associated with growth hormone in the healthy young. Expand
Long-term safety of recombinant human growth hormone in children.
TLDR
After more than 20 yr, leukemia, a major safety issue initially believed associated with GH, has not been confirmed, but other signals, including risk of second malignancies in patients previously treated with irradiation, have been detected or confirmed through the NCGS. Expand
Absence of a telomere maintenance mechanism as a favorable prognostic factor in patients with osteosarcoma.
TLDR
The absence of a detectable TMM may identify a favorable clinical subset of OS patients and the likelihood of detecting correlations between TMMs and clinical outcome in studies of certain other tumor types might be improved if, in addition to TA, ALT is included in future analyses. Expand
Systematic Review: The Safety and Efficacy of Growth Hormone in the Healthy Elderly
TLDR
The researchers reviewed all clinical trials of GH to determine if it is safe and effective in the healthy elderly and found that GH had no important effects on body composition but led to frequent adverse effects, most notably soft tissue edema and arthralgias. Expand
CTCF Regulates Allelic Expression of Igf2 by Orchestrating a Promoter-Polycomb Repressive Complex 2 Intrachromosomal Loop
TLDR
Insight is offered into general epigenetic mechanisms by which CTCF governs gene expression by orchestrating chromatin loop structures and by serving as a DNA-binding protein scaffold to recruit and bind polycomb repressive complexes. Expand
Serum 25-hydroxyvitamin D, parathyroid hormone, and mortality in older men.
TLDR
Lower 25(OH)D levels were not associated with an increased risk of all-cause or cause-specific mortality in older men, and higher PTH levels were associated with a modest increase in mortality risk. Expand
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